ArticleMolecular pharmaceutics2025
Highly Water-Soluble Microneedle Patch for Short Wear Time and Rapid Drug Delivery.
Article in Molecular pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Hydrogel microneedles functioning in pathological surroundings: where soft materials overcome hard scars.Materials today. Bio · 2026Review
- Triple-layered core-shell microneedle patch for sustained analgesic delivery and chondroprotection in osteoarthritis.Journal of controlled release : official journal of the Controlled Release Society · 2026Article
- Article
- Single Polysaccharide Dissolvable Microneedles for Painless Local Anesthesia: Fabrication, Characterization, andACS biomaterials science & engineering · 2025Article
- Microneedle-Tissue Interaction Across Varying Biological and Mechanical Conditions.Biosensors · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Treatment of acute medical conditions such as pain would benefit from rapid drug delivery and improved ease of administration of local anesthetics that currently have a slow onset of action by topical or oral administration and require expert administration by injection. To address this need, microneedle (MN) patches containing needlelike projections made from a polymer/drug matrix can be painlessly pressed into the skin for local or systemic drug delivery. To improve the speed and ease of drug delivery, we present a rapidly dissolving, highly water-soluble MN patch, which minimizes the wear time to 10 s to improve drug delivery in situations where rapid delivery with simplified administration is needed. MNs were made of polyvinylpyrrolidone (PVP), which is soluble in both water (enabling dissolution in the skin) and polar organic solvents (facilitating coformulation with lidocaine (L)). The addition of a highly water-soluble salt, sodium bicarbonate (NaB), to PVP/L MNs allowed for 60% faster MN dissolution in porcine skin ex vivo. Further addition of citric acid to generate effervescence upon reaction with NaB did not further decrease the MN dissolution time in the pig skin and led to poor shelf-life stability due to premature effervescence during storage. The PVP/L/NaB MNs delivered 23.8 ± 3.5 μg lidocaine to the skin ex vivo, well above the expected dose for local analgesic effect. Our highly water-soluble PVP/L/NaB MN design enables shorter wear time for faster delivery compared to the oral or topical route and easier administration compared to injection currently used for the delivery of drugs needing a rapid onset of action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.