Evidence map›Paper›PMID 39624968›Full record

ArticleAnnals of medicine2024

FOXG1 interaction with SATB2 promotes autophagy to alleviate neuroinflammation and mechanical abnormal pain in rats with lumbar disc herniation.

Zhanchao Wang, Yifei Gu, Hui Wang, Yu Chen, Huajiang Chen, Xinwei Wang, Wen Yuan

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PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhanchao WangDepartment of Orthopaedics, Changzheng Hospital, Naval Medical University, Shanghai, China.
Yifei GuDepartment of Orthopaedics, Changzheng Hospital, Naval Medical University, Shanghai, China.
Hui WangDepartment of Orthopaedics, Changzheng Hospital, Naval Medical University, Shanghai, China.
Yu ChenDepartment of Orthopaedics, Changzheng Hospital, Naval Medical University, Shanghai, China.
Huajiang ChenDepartment of Orthopaedics, Changzheng Hospital, Naval Medical University, Shanghai, China.
Xinwei WangDepartment of Orthopaedics, Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID 0000-0001-6057-8400
Wen YuanDepartment of Orthopaedics, Changzheng Hospital, Naval Medical University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMost patients with lumbar disc herniation can be relieved or cured by surgical or non-surgical treatment; however, postoperative persistent radiculopathy is common. This study demonstrates the regulation of autophagy by the FOXG1/SATB2 axis in lumbar disc herniation (LDH).

methodsRat dorsal root neurons were induced with TNF-α

resultsTNF-α induced low expression of FOXG1 and SATB2 in dorsal root ganglion (DRG) neurons of rats. TNF-α induced an increase in p62 protein and a decrease in LC3II/I and Beclin-1 proteins in neurons, which were blocked by oe-FOXG1. oe-FOXG1 suppressed inflammation and apoptosis in TNF-α-induced DRG neurons and LDH rats and promoted the expression of Cyclin D1, PCNA, and Ki67. Many miRNAs were increased in the peripheral blood of LDH rats, but decreased after

conclusionsMiR-31a-5p/SATB2 is involved in the treatment of

Indexed as

AutophagyForkhead Transcription FactorsGanglia, SpinalIntervertebral Disc DisplacementMatrix Attachment Region Binding ProteinsRats, Sprague-DawleyTranscription FactorsAnimalsApoptosisDisease Models, AnimalLumbar VertebraeMaleNerve Tissue ProteinsNeuroinflammatory DiseasesRatsTumor Necrosis Factor-alphaForkhead Transcription FactorsMatrix Attachment Region Binding ProteinsNerve Tissue ProteinsSATB2 protein, ratTranscription FactorsTumor Necrosis Factor-alphaautophagyFOXG1Lumbar disc herniationosteoclast differentiationSATB2

Identifiers

PMID39624968
PMCPMC11616759

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.