Evidence map›Paper›PMID 39624967›Full record

ArticleAnnals of medicine2024

Astilbin exerts anti-hypersensitivity by regulating metabolic demand and neuronal activity in rodent model of neuropathic pain.

Qiru Wang, Dongxia Duan, Chao Luo, Jinlu Huang, Jinbao Wei, Yang Zhang, Ke Zhang, Tong Zhou, Wei Wang, Shaoxin Yang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qiru WangDepartment of Pharmacy, Shanghai Cancer Center, Fudan University, Minhang Branch, Shanghai, China.
Dongxia DuanShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chao LuoShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jinlu HuangDepartment of Pharmacy, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jinbao WeiDepartment of Pharmacy, Xiamen Haicang Hospital, Xiamen, China.
Yang ZhangShanghai Jiao Tong University Hospital, Shanghai, China.
Ke ZhangDepartment of Pharmacy, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tong ZhouShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wei WangShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shaoxin YangShanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China.
Le MaShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objective

methodsSpinal nerve ligation (SNL) and formalin-induced pain models were employed. Network pharmacology and bioinformatics were utilized to identify targets. Verification was performed through spinal cord double immunofluorescence staining, quantitative PCR and whole-cell recording techniques.

resultsIn experiments conducted on neuropathic rats, both systemic and intrathecal administration of astilbin, an essential constituent, exhibited a noteworthy and dose-dependently decrease in chronic and acute pain behaviours. The ED

conclusionsIn summary, this study provides evidence that astilbin alleviates pain by modulating neuronal metabolic processes and synaptic homeostasis.

Indexed as

Disease Models, AnimalFlavonolsNeuralgiaRats, Sprague-DawleyAnalgesicsAnimalsMaleNetwork PharmacologyNeuronsRatsSpinal CordSpinal NervesAnalgesicsastilbinFlavonolsAstilbinmetabolic homeostasisnetwork pharmacologysynaptic transmissionWGCNA

Identifiers

PMID39624967
PMCPMC11616750

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.