Evidence map›Paper›PMID 39624926›Full record

ArticleInternational forum of allergy & rhinology2025

Comparison of surveillance modalities in the surveillance of sinonasal squamous cell carcinoma recurrence: A multi-institutional study.

Saawan D Patel, Isha K Thapar, Alan D Workman, Dana F Lopez, Benjamin F Bitner, Hannah B Bukzin, David K Lerner, Jadyn Wilensky, Jennifer E Douglas, James N Palmer and 4 more

Abstract readMulticenter StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International forum of allergy & rhinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Saawan D PatelDepartment of Otolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-3185-7026
Isha K ThaparDepartment of Otolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Alan D WorkmanDepartment of Otolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-9573-6472
Dana F LopezDepartment of Otolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Benjamin F BitnerDepartment of Otolaryngology, Head and Neck Surgery, University of California Irvine, Orange, California, USA.
Hannah B BukzinDepartment of Otolaryngology, Head and Neck Surgery, Northwell Health, New York, New York, USA.
David K LernerDepartment of Otolaryngology, Head and Neck Surgery, University of Miami, Miami, Florida, USA.ORCID 0000-0002-0431-2920
Jadyn WilenskyDepartment of Otolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jennifer E DouglasDepartment of Otolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-3634-2067
James N PalmerDepartment of Otolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Nithin D AdappaDepartment of Otolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Charles C L TongDepartment of Otolaryngology, Head and Neck Surgery, Northwell Health, New York, New York, USA.
Edward C KuanDepartment of Otolaryngology, Head and Neck Surgery, University of California Irvine, Orange, California, USA.ORCID 0000-0003-3475-0718
Michael A KohanskiDepartment of Otolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecurrence of sinonasal squamous cell carcinoma (SNSCC) follows an aggressive course, and early detection is paramount. This study identifies the parameters of different surveillance modalities.

methodsWe conducted a retrospective study of 105 SNSCC patients at three academic institutions from November 2009 to July 2024. Patient records were reviewed for demographics, tumor characteristics, endoscopy, CT, PET/CT, and MRI findings. Multivariable analyses were performed in RStudio.

resultsMean time to recurrence was 12.1 months (SD 13.9 months). Patients with higher Charlson Comorbidity Index (p = 0.041), endoscopic surgical approach (p = 0.015), and suspicious surveillance findings (p = 0.029) had higher rates of recurrence. Endoscopy showed a sensitivity of 18.5% and specificity of 99.2%, with a positive predictive value (PPV) of 45.5% and negative predictive value (NPV) of 97.0%. CT had a sensitivity of 75.0% and specificity of 100.0%, with a PPV of 100.0% and NPV of 97.6%. PET/CT demonstrated a sensitivity of 95.2% and specificity of 90.8%, with a PPV of 64.5% and NPV of 97.6%. MRI showed a sensitivity of 72.4% and specificity of 97.1%, with a PPV of 65.6% and NPV of 97.9%. The median time from the last normal surveillance to recurrence was 2.07 months for endoscopy, 8.61 months for CT, 8.15 months for PET/CT, and 6.49 months for MRI.

conclusionsThe high specificity and NPV of endoscopy, alongside the high sensitivity of PET/CT, support a multimodal approach for surveillance. Given the mean onset of SNSCC recurrence at 12.1 months, surveillance beyond the National Comprehensive Cancer Network's asymptomatic 6-month guideline is warranted, and follow-up should be tailored to patient-specific risk factors.

Indexed as

Carcinoma, Squamous CellNeoplasm Recurrence, LocalParanasal Sinus NeoplasmsAdultAgedAged, 80 and overEndoscopyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPositron Emission Tomography Computed TomographyRetrospective StudiesSensitivity and SpecificityTomography, X-Ray Computedendoscopyfollow‐upimagingrecurrencesinonasal sccsurveillance

Identifiers

PMID39624926
PMCPMC11970448

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.