ArticleCirculation. Arrhythmia and electrophysiology2024
Artificial Intelligence-Based Feature Analysis of Pulmonary Vein Morphology on Computed Tomography Scans and Risk of Atrial Fibrillation Recurrence After Catheter Ablation: A Multi-Site Study.
Article in Circulation. Arrhythmia and electrophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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25 authors.
Golnoush AsaeikheybariDepartment of Electrical, Computer and Systems Engineering, School of Engineering, Case Western Reserve University, Cleveland, OH (G.A.).ORCID 0000-0002-5550-3487
Majd El-HarasisDivision of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, TN (M.E.-H., M.B.S., B.V.).
Amit GuptaDepartment of Radiology, University Hospitals Cleveland Medical Center, Cleveland, OH (A.G.).ORCID 0000-0001-5345-6763
M Benjamin ShoemakerDivision of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, TN (M.E.-H., M.B.S., B.V.).ORCID 0000-0001-6824-7155
John BarnardDepartment of Quantitative and Health Sciences (J.B., H.S.), Lerner Research Institute.ORCID 0000-0003-2403-8268
Joshua HunterCase Western Reserve University School of Medicine, Cleveland, OH (J.H., K.P.).ORCID 0000-0002-5360-7899
Han SunDepartment of Quantitative and Health Sciences (J.B., H.S.), Lerner Research Institute.ORCID 0000-0001-9164-5282
Hyun Su KimDepartment of Cardiovascular and Metabolic Sciences (H.S.K., T.S., W.T., B.E., S.Y.W., D.R.V.W., M.K.C.), Lerner Research Institute.
Taylor SchillingDepartment of Cardiovascular and Metabolic Sciences (H.S.K., T.S., W.T., B.E., S.Y.W., D.R.V.W., M.K.C.), Lerner Research Institute.ORCID 0009-0009-9755-6331
William TelferDepartment of Cardiovascular and Metabolic Sciences (H.S.K., T.S., W.T., B.E., S.Y.W., D.R.V.W., M.K.C.), Lerner Research Institute.ORCID 0009-0009-8706-6670
Britta EldridgeDepartment of Cardiovascular and Metabolic Sciences (H.S.K., T.S., W.T., B.E., S.Y.W., D.R.V.W., M.K.C.), Lerner Research Institute.
Po-Hao ChenDepartment of Diagnostic Radiology, Imaging Institute, Cleveland, OH (P.-H.C.).ORCID 0000-0001-7698-5289
Abhishek MidyaWallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA (A. Midya, A. Madabhushi).ORCID 0000-0003-2149-7098
Bibin VargheseDivision of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, TN (M.E.-H., M.B.S., B.V.).ORCID 0000-0001-5637-4560
Samuel J HarwoodCleveland Clinic Lerner College of Medicine of Case Western Reserve University (S.J.H., A.I., D.R.V.W., M.K.C.).
Alison JinCase Western Reserve University School of Medicine, Cleveland, OH (A.J.).ORCID 0009-0006-6512-8461
Sojin Y WassDepartment of Cardiovascular and Metabolic Sciences (H.S.K., T.S., W.T., B.E., S.Y.W., D.R.V.W., M.K.C.), Lerner Research Institute.ORCID 0000-0001-9354-0011
Aleksandar IzdaCleveland Clinic Lerner College of Medicine of Case Western Reserve University (S.J.H., A.I., D.R.V.W., M.K.C.).ORCID 0009-0008-9796-9913
Kevin ParkCase Western Reserve University School of Medicine, Cleveland, OH (J.H., K.P.).
David R Van WagonerDepartment of Cardiovascular and Metabolic Sciences (H.S.K., T.S., W.T., B.E., S.Y.W., D.R.V.W., M.K.C.), Lerner Research Institute.ORCID 0000-0001-8250-9828
Animesh TandonCleveland Clinic Children's Center for Artificial Intelligence (C4AI), Department of Heart, Vascular, and Thoracic, Children's Institute, Cleveland Clinic Children's (A.T.).ORCID 0000-0001-9769-8801
Mina K ChungDepartment of Cardiovascular and Metabolic Sciences (H.S.K., T.S., W.T., B.E., S.Y.W., D.R.V.W., M.K.C.), Lerner Research Institute.ORCID 0000-0002-7835-6045
Anant MadabhushiWallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA (A. Midya, A. Madabhushi).ORCID 0000-0002-5741-0399
Funding
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7M
Project 3 Genes to Omics-Informed Drugs: Drug Repositioning and Testing to Prevent AF ProgressionsP01HL158502 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI David R Van Wagoner · 2022 to 2026
$16.9M
Functional Genomics of Atrial Fibrillation in Human AtriaR01HL111314 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BARNARD, JOHN, CHUNG, MINA KAY · 2012 to 2019
$6.1M
Pathology CoreU54CA254566 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MADABHUSHI, ANANT · 2020 to 2024
$5.0M
Computer-Assisted Histologic Evaluation of Cardiac Allograft RejectionR01HL151277 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MADABHUSHI, ANANT, MARGULIES, KENNETH BER · 2020 to 2023
$3.2M
Oral Cavity Quantitative Histomorphometric Risk Classifier (OHbIC) in Oral Cavity Squamous Cell Carcinoma (OC-SCC)R01CA249992 · NCI · EMORY UNIVERSITY · PI LEWIS, JAMES, MADABHUSHI, ANANT · 2021 to 2025
$3.2M
Computerized histologic image predictor of cancer outcomeR01CA202752 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI FELDMAN, MICHAEL D, GANESAN, SHRIDAR · 2016 to 2020
$3.1M
Prostate cancer risk stratification via computational 3D pathologyR01CA268207 · NCI · UNIVERSITY OF WASHINGTON · PI Jonathan T.C. Liu, Anant Madabhushi · 2022 to 2026
$3.1M
Quantitative Histomorphometric Risk Classifier (QuHbIC) in HPV + Oropharyngeal CarcinomaR01CA220581 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI KOYFMAN, SHLOMO, LEWIS, JAMES · 2018 to 2023
$3.1M
Computerized Histologic Risk Predictor (CHiRP) for Early Stage Lung CancersR01CA216579 · NCI · EMORY UNIVERSITY · PI FU, PINGFU, LLOYD, MARK · 2018 to 2023
$3.1M
Prognostic and Predictive Digital Tissue Image Assay for Prostate CancerR01CA268287 · NCI · EMORY UNIVERSITY · PI GUPTA, SHILPA, LAL, PRITI · 2022 to 2025
$3.0M
MR Fingerprinting and Computerized Decision Support for Prostate CancerR01CA208236 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GULANI, VIKAS, PONSKY, LEE EVAN · 2017 to 2022
backgroundAtrial fibrillation (AF) recurrence is common after catheter ablation. Pulmonary vein (PV) isolation is the cornerstone of AF ablation, but PV remodeling has been associated with the risk of AF recurrence. We aimed to evaluate whether artificial intelligence-based morphological features of primary and secondary PV branches on computed tomography images are associated with AF recurrence post-ablation.
methodsTwo artificial intelligence models were trained for the segmentation of computed tomography images, enabling the isolation of PV branches. Patients from Cleveland Clinic (N=135) and Vanderbilt University (N=594) were combined and divided into 2 sets for training and cross-validation (D
resultsFeatures relating to primary PVs were found to be associated with AF recurrence. The M
conclusionsThis largest multi-institutional study to date revealed associations between artificial intelligence-extracted morphological features of the primary PV branches with AF recurrence in 809 patients from 3 sites. Future work will focus on enhancing the predictive ability of the classifier by integrating clinical, structural, and morphological features, including left atrial appendage and left atrium-related characteristics.
Indexed as
Atrial FibrillationCatheter AblationPredictive Value of TestsPulmonary VeinsRecurrenceAgedArtificial IntelligenceFemaleHumansMaleMiddle AgedOhioRadiographic Image Interpretation, Computer-AssistedReproducibility of ResultsRetrospective StudiesRisk Assessmentartificial intelligenceatrial fibrillationcatheter ablationfractalspulmonary veins
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Artificial Intelligence-Based Feature Analysis of Pulmonary Vein Morphology on Computed Tomography Scans and Risk of Atrial Fibrillation Recurrence After Catheter Ablation: A Multi-Site Study. · full record | OpenQuestion