Evidence map›Paper›PMID 39624860›Full record

ArticleThe FEBS journal2025

Aberrant extracellular dopamine clearance in the prefrontal cortex exhibits ADHD-like behavior in NCX3 heterozygous mice.

Ryo Inagaki, Satomi Kita, Nozomu Niwa, Kohji Fukunaga, Takahiro Iwamoto, Shigeki Moriguchi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The FEBS journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ryo InagakiResearch Center for Pharmaceutical Development, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Satomi KitaDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Nozomu NiwaResearch Center for Pharmaceutical Development, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Kohji FukunagaDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Takahiro IwamotoDepartment of Pharmacology, Faculty of Medicine, Fukuoka University, Japan.
Shigeki MoriguchiResearch Center for Pharmaceutical Development, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.ORCID 0009-0006-0587-1114

Funding

AMED (Interdisciplinary and Emerging Brain Research Program: iBrain/MINDS) JP22wm052531Astellas Foundation for Research on Metabolic DisordersMinistry of Education, Culture, Sports, Science and Technology and the Ministry of Health and Welfare of Japan 21K06794Ministry of Education, Culture, Sports, Science and Technology and the Ministry of Health and Welfare of Japan 21K15349Ministry of Education, Culture, Sports, Science and Technology and the Ministry of Health and Welfare of Japan 24K09828
6 · The paper itself

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that involves dopaminergic dysfunction in the prefrontal cortex (PFC), manifesting hyperactivity, inattention, and cognitive deficits. However, the ADHD-associated candidate genes underlying dopaminergic neurotransmission alterations remain poorly defined. Here, we identified the abundant localization of sodium-calcium exchanger 3 (NCX3) levels in the dopaminergic neurons of the ventral tegmental area, a major source of dopaminergic innervation to the PFC. We confirmed that NCX3 knockdown in N27 cells caused aberrant dopamine influx through the strong interaction between calcium/calmodulin-dependent protein kinase II alpha and dopamine transporter. In addition, we assessed behavioral changes and underlying molecular properties in NCX3 heterozygous (NCX3

Indexed as

Attention Deficit Disorder with HyperactivityDopaminePrefrontal CortexSodium-Calcium ExchangerAnimalsBehavior, AnimalCalcium-Calmodulin-Dependent Protein Kinase Type 2Dopamine Plasma Membrane Transport ProteinsDopaminergic NeuronsHeterozygoteMaleMethylphenidateMiceMice, Inbred C57BLMice, KnockoutVentral Tegmental AreaCalcium-Calmodulin-Dependent Protein Kinase Type 2Camk2a protein, mouseDopamineDopamine Plasma Membrane Transport ProteinsMethylphenidateSlc8a3 protein, mouseSodium-Calcium ExchangerADHDCaMKIIDATdopamineNCX3

Identifiers

PMID39624860
PMCPMC11734882

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.