ArticleFrontiers in pharmacology2024
Efficient generation of HPLC and FTIR data for quality assessment using time series generation model: a case study on Tibetan medicine Shilajit.
Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Chemical Analysis of Native Himalayan Shilajit: An Evaluation of an Ayurvedic Formulation.ACS omega · 2025Article
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6 authors.
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Abstract
Background: The scarcity and preciousness of plateau characteristic medicinal plants pose a significant challenge in obtaining sufficient quantities of experimental samples for quality evaluation. Insufficient sample sizes often lead to ambiguous and questionable quality assessments and suboptimal performance in pattern recognition. Shilajit, a popular Tibetan medicine, is harvested from high altitudes above 2000 m, making it difficult to obtain. Additionally, the complex geographical environment results in low uniformity of Shilajit quality. Methods: To address these challenges, this study employed a deep learning model, time vector quantization variational auto- encoder (TimeVQVAE), to generate data matrices based on chromatographic and spectral for different grades of Shilajit, thereby increasing in the amount of data. Partial least squares discriminant analysis (PLS-DA) was used to identify three grades of Shilajit samples based on original, generated, and combined data. Results: Compared with the originally generated high performance liquid chromatography (HPLC) and Fourier transform infrared spectroscopy (FTIR) data, the data generated by TimeVQVAE effectively preserved the chemical profile. In the test set, the average matrices for HPLC, FTIR, and combined data increased by 32.2%, 15.9%, and 23.0%, respectively. On the real test data, the PLS-DA model's classification accuracy initially reached a maximum of 0.7905. However, after incorporating TimeVQVAE-generated data, the accuracy significantly improved, reaching 0.9442 in the test set. Additionally, the PLS-DA model trained with the fused data showed enhanced stability. Conclusion: This study offers a novel and effective approach for researching medicinal materials with small sample sizes, and addresses the limitations of improving model performance through data augmentation strategies.
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