ArticleCureus2024
An Experimental Study to Evaluate the Antidepressant Effect of Zileuton and Aqueous Extract of Phyllanthus emblica in Unpredictable Chronic Mild Stress-Induced Depression in Albino Mice.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionOxidative stress and proinflammatory signaling in the brain have been found to have a significant role in the pathogenesis of depression. Therefore, drugs that reduce oxidative stress and neuroinflammation may be helpful in depression as monotherapy or as an adjunct to conventional antidepressants. Zileuton, a 5-lipoxygenase inhibitor, has been identified as a putative antidepressant in an in vitro study. It was shown to modulate the proinflammatory macrophage response in the brain and, hence, neuroinflammation. Currently, there are no antidepressants that target the inflammatory component of depression. Hence, this would be a desirable addition to our armamentarium against depression, particularly in patients with poor responses to antidepressants.
methodsThe primary aim of this study was to evaluate whether zileuton and aqueous extract of
resultsIt was observed that zileuton and aqueous extract of
conclusionAccording to our study's findings, zileuton and
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