Evidence map›Paper›PMID 39624524›Full record

ArticleCureus2024

Diagnosing Primary Hemophagocytic Lymphohistiocytosis in an Adult: A Case Report.

Kinaya K Smith, Linzi M Hobbs, Ravi Narra

Abstract readCase Reports
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kinaya K SmithDepartment of Internal Medicine, Medical College of Wisconsin, Milwaukee, USA.
Linzi M HobbsDepartment of Internal Medicine, Medical College of Wisconsin, Milwaukee, USA.
Ravi NarraDepartment of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary hemophagocytic lymphohistiocytosis (HLH) is a rare, often fatal immune disorder characterized by an overactivation of the immune system. This disease is more common in children but has been known to occur in the occasional adult. The criteria for diagnosis in children do not correlate well with diagnosis in adults, and the numerous variations of presentation in adults often lead to a delay in diagnosis and treatment initiation. This case report highlights an example of primary HLH in a 41-year-old female patient who experienced a delay in diagnosis and appropriate treatment due to the similarity of her early symptoms to more common conditions. Delays in diagnosis and treatment can lead to poor outcomes, including death. Thus, it is important for providers to be able to recognize the varying signs and symptoms of primary HLH in an adult to ensure treatment is initiated as early as possible in the disease course.

Indexed as

allogenic bone marrow transplantbone marrow biopsyhemophagocytic lymphohistiocytosis (hlh)neurosarcoidosispancytopenia

Identifiers

PMID39624524
PMCPMC11610629

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.