ArticleMedicine international
MicroRNAs and hypospadias: A systematic review.
Article in Medicine international. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Tacrolimus modulates the PI3K AKT mTOR pathway in retinal epithelial cells under inflammatory stress.Scientific reports · 2025Article
- Evaluation of Gene Expression and the Regulatory Role of microRNAs Related to the Mitogen-Activated Protein Kinase Signaling Pathway in Human Retinal Pigment Epithelial Cells Treated With Lipopolysaccharide A and Tacrolimus.Mediators of inflammation · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to summarize what is known about the role of microRNAs (miRNAs/miRs) in relation to hypospadias. Therefore, a systematic review was performed by consulting the electronic databases, MEDLINE (PubMed) and Embase. The search strategy consisted of both MeSH and free text terms, including hypospadias AND miRNA. Only articles written in the English language were included. In the selection process, three authors assessed the studies defined through the search strategy based on titles and abstracts. The authors then analyzed the complete articles and selected studies conforming to the eligibility criteria. Studies that did not align with the adopted criteria were excluded based on the limits set by the initial search strategy: Publication details, study design and participant characteristics. Articles presenting original data on miRNAs associated with hypospadias and including information on miRNA detection and analysis methods were extracted from the selected articles. The included studies presented miRNA extraction from blood samples, preputial or penile tissues, urethral epithelium and/or foreskin fibroblasts. The compiled data focused on the regulatory role of miR-494, miR-145, miR-6756-5p, miR-182, miR-200c, miR-210 and miR-1199-5p in vital cell biological processes, such as wound healing, and cell proliferation, growth and apoptosis. These results proposed that miRNAs may serve as key molecules that merit further investigation; for instance, they may be used as potential biomarkers, diagnostic markers and, eventually, as pharmaceutical agents in hypospadias.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.