ArticleJournal of biomedical optics2025
Digital instrument simulator to optimize the development of hyperspectral systems: application for intraoperative functional brain mapping.
Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Advancements in broadband near-infrared spectroscopy instrumentation for the assessment ofJournal of biomedical optics · 2025Pooled it
- Simulation-driven probe design and dual-wavelength optimization for wearable cerebral oxygenation monitoring.Biomedical optics express · 2026Article
- OptoCENTAL: a standardized, bench-testing platform based on phantoms for validating optical systems aimed at clinical monitoring of the placenta.Journal of biomedical optics · 2026Article
- Special Section Guest Editorial: JBO Special Section on Hyperspectral Imaging.Journal of biomedical optics · 2025Article
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Authors and funding
8 authors.
Funding
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Abstract
Significance: Intraoperative optical imaging is a localization technique for the functional areas of the human brain cortex during neurosurgical procedures. These areas can be assessed by monitoring cerebral hemodynamics and metabolism. Robust quantification of these biomarkers is complicated to perform during neurosurgery due to the critical context of the operating room. In actual devices, the inhomogeneities of the optical properties of the exposed brain cortex are poorly taken into consideration, which introduce quantification errors of biomarkers of brain functionality. Moreover, the best choice of spectral configuration is still based on an empirical approach. Aim: We propose a digital instrument simulator to optimize the development of hyperspectral systems for intraoperative brain mapping studies. This simulator can provide realistic modeling of the cerebral cortex and the identification of the optimal wavelengths to monitor cerebral hemodynamics (oxygenated Approach: The digital instrument simulator is computed with white Monte Carlo simulations of a volume created from a real image of exposed cortex. We developed an optimization procedure based on a genetic algorithm to identify the best wavelength combinations in the visible and near-infrared range to quantify concentration changes in Results: The digital instrument allows the modeling of intensity maps collected by a camera sensor as well as images of path length to take into account the inhomogeneities of the optical properties. The optimization procedure helps to identify the best wavelength combination of 18 wavelengths that reduces the quantification errors in Conclusions: We proposed a digital instrument simulator to optimize the development of hyperspectral systems for intraoperative brain mapping studies. This digital instrument simulator and this optimization framework could be used to optimize the design of hyperspectral imaging devices.
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