ArticleIranian journal of veterinary research2024
The effects of advanced age on electrocardiographic parameters, lipid profile and redox balance in male rats: role of long-term cinnamon consumption.
Article in Iranian journal of veterinary research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Oxidative stress damages biological molecules and plays a role in aging-related cardiovascular diseases. Aims: This study aimed to assess the changes in electrocardiography and lipid profile as well as indicators of the oxidant-antioxidant system with advanced age in rats. Also, the possible beneficial effect of cinnamon on these parameters has been investigated. Methods: In this experimental study, thirty male Sprague-Dawley rats were randomly assigned to five groups. The control groups of 12, and 20 months received a normal chow diet, while the investigation group was given a control diet mixed with cinnamon powder (1% of the diet). Also, a control group of 3-month-old rats was considered for assessment of age effects. Systolic blood pressure (SBP), ECG, serum lipid profiles, and heart oxidative stress markers were compared in different groups at the end of the study. Results: Systolic BP, serum cholesterol, HDL and LDL-cholesterol, the heart level of malondialdehyde (MDA) and nitric oxide metabolites (NOx), the ECG parameters including QRS duration, PR, T Conclusion: The results demonstrated that aging is associated with ECG alteration, oxidative stress, and an increase in TC, LDL, and HDL cholesterol. Cinnamon improved electrical heart activity in aged rats (20 months) by restoration of QRS duration and T
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