Evidence map›Paper›PMID 39624179›Full record

ArticleWorld journal of pharmaceutical science and research2024

IONIC NANOMEDICINE STRATEGY TO DEVELOP EFFECTIVE CHEMO-PTT COMBINATION CANCER THERAPEUTICS.

Mujeebat Bashiru, Mavis Forson, Arisha Ishtiaq, Adeniyi Oyebade, Samantha Macchi, Shehzad Sayyed, Nawab Ali, Robert J Griffin, Adegboyega K Oyelere, Noureen Siraj

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of pharmaceutical science and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mujeebat BashiruDepartment of Chemistry, University of Arkansas at Little Rock, Little Rock, AR 72204, USA.
Mavis ForsonDepartment of Chemistry, University of Arkansas at Little Rock, Little Rock, AR 72204, USA.
Arisha IshtiaqDepartment of Chemistry, University of Arkansas at Little Rock, Little Rock, AR 72204, USA.
Adeniyi OyebadeDepartment of Chemistry, University of Arkansas at Little Rock, Little Rock, AR 72204, USA.
Samantha MacchiDepartment of Chemistry, University of Arkansas at Little Rock, Little Rock, AR 72204, USA.
Shehzad SayyedDepartment of Chemistry, University of Arkansas at Fayetteville, AR 72701, USA.
Nawab AliDepartment of Biology, University of Arkansas at Little Rock, Little Rock, AR 72204, USA.
Robert J GriffinUniversity of Arkansas for Medical Sciences, Winthrop P. Rockefeller Cancer Institute, Arkansas Nanomedicine Center, Department of Radiation Oncology, 4301 W Markham St, Little Rock, AR 72205, USA.
Adegboyega K OyelereSchool of Chemistry and Biochemistry, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.
Noureen SirajDepartment of Chemistry, University of Arkansas at Little Rock, Little Rock, AR 72204, USA.

Funding

Understanding Hesitant AdoptersP20GM103429 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Lawrence E Cornett · 2012 to 2026
$60.9M
NIGMS NIH HHS P20 GM103429
6 · The paper itself

Abstract

Herein, a detailed investigation of nanodrugs derived by combining a chemotherapy (chemo) and photothermal therapy (PTT) approaches to enhance chemo drug efficacy is presented. Tamoxifen and its metabolite; N-desmethyltamoxifen are the selected chemo drugs that were electrostatically attached with a PTT agent, NaIR820, via a metathesis approach to develop two different ionic material (IM)-based chemo-PTT drugs. Ionic nanomaterials (INMs) were synthesized using reprecipitation method, and these carrier- free nanoparticles were characterized in detail. Photophysical properties of NaIR820 parent compound, and their derived chemo-PTT IMs and INMs revealed significant alterations in absorption and fluorescence emission spectra of IR820. Photophysical results demonstrated that INMs exhibited promising characteristics as photothermal agents that are beneficial for light mediated therapy. Photothermal conversion efficiency and reactive oxygen quantum yield of INMs and IMs also improved significantly in comparison to the parent NaIR820 compound. In vitro cell viability studies demonstrated improved dark and light cytotoxicity of chemo-PTT INMs as compared to treatments that involved either the mixture of both soluble parent drugs and chemo or PTT drugs independently. Moreso, apoptotic cell death signal was greatly enhanced for the INMs as opposed to the parent chemo drugs.

Indexed as

Cell death mechanismCombination indexCytotoxicityIonic nanomedicineTamoxifen

Identifiers

PMID39624179
PMCPMC11610177

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.