ReviewClinical obesity2025
Glucocorticoids and HPA axis regulation in the stress-obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions.
Review in Clinical obesity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed.
- Behavioral Factors Associated With ≥ 15% Versus < 5% Weight Loss in Adults With Severe Obesity: A Retrospective Clinical Study.Obesity science & practice · 2026Article
- Article
- Associations of Emotional Eating with Perceived Stress and Sleep Quality Among University Students: A Nationwide Cross-Sectional Study.Nutrients · 2026Article
- Article
- Psychological Determinants of the Weight Cycle: A Review of Perceived Stress and Self-Efficacy.Current obesity reports · 2026Review
- Association between perceived stress and metabolic parameters: a systematic review and meta-analysis.Diabetology & metabolic syndrome · 2026Review
- Comparison of Salivary Stress Biomarkers in Patients with and without Periodontal Diseases: A Cross-sectional Study.Oral health & preventive dentistry · 2026Article
- Article
- Nonlinear association between body mass index, perceived discrimination, and psychological sub-health problems among adolescents: risks of undernutrition versus overnutrition.BMC psychology · 2026Article
- Glucose as a Biomarker for Stress in Firefighters.Journal of occupational and environmental medicine · 2026Article
- Review
- Effect of Multi-Antioxidant Supplement on Lipid Profile, Occupational Fatigue, Work Stress, and Hair Cortisol in Administrative Workers with and Without Obesity: A Quasi-Experimental Pilot Study.Healthcare (Basel, Switzerland) · 2026Article
- Interplay of Vitamin D3, Wnt/β-Catenin Pathway, and Oxidative DNA Injury in CMS-Induced Depression Model.Biomedicines · 2026Article
- Pharmacological evaluation of Lonafarnib in reversing neurobehavioral, neurochemical and metabolic deficit in mouse models of chronic unpredictable mild stress (CUMS).Metabolic brain disease · 2026Article
- From Molecules to Meaning: Integrating Neuropeptides, Sociostasis, and Hormesis in the Brain-Heart Axis.Current issues in molecular biology · 2026Review
- Low fruit and vegetable intake in children: a dietary stressor raising renal ammonium and adrenal cortisol secretion.Pflugers Archiv : European journal of physiology · 2026Article
- Machine learning-based identification of abnormal functional connectivity in obesity across different metabolic states.Communications medicine · 2026Article
- Prevalence of Emotional Eating and Its Relationship with Anthropometric and Biochemical Indicators in University Students.Nutrients · 2026Article
- Association between high-density lipoprotein-related inflammation index and prevalence of sleep disorders with depression as a mediator.European archives of psychiatry and clinical neuroscience · 2026Article
- Health among sexual and gender minority people affected by armed conflict and forced displacement: Call for a biocultural and minority stress framework.Social science & medicine (1982) · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Chronic stress, characterized by increased long-term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and obesity. We discuss three biological stress systems-the autonomic nervous system, the hypothalamus-pituitary-adrenal (HPA) axis and the immune system-and their link with obesity, with a particular focus on the HPA axis. The role of cortisol and its regulatory variations (including glucocorticoid rhythmicity and altered sensitivity) in adipose tissue biology and obesity development is discussed. Moreover, we highlight the physiological, affective, cognitive and behavioural dimensions of the stress response offering a deeper understanding of how stress contributes to obesity development and vice versa. Finally, stress as a treatment target for obesity is discussed. We conclude that the link between stress and obesity is complex and multifaceted, influenced by physiological, affective, cognitive and behavioural stress response mechanisms, which especially when chronically present, play a key role in the development of obesity and associated cardiometabolic diseases. This necessitates integrated approaches tailored to individual needs, including lifestyle modifications, behavioural interventions, psychosocial support and possible additional pharmacological interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.