Evidence map›Paper›PMID 39623505›Full record

ArticleZoological letters2024

A transphyletic study of metazoan β-catenin protein complexes.

Ivan Mbogo, Chihiro Kawano, Ryotaro Nakamura, Yuko Tsuchiya, Alejandro Villar-Briones, Yoshitoshi Hirao, Yuuri Yasuoka, Eisuke Hayakawa, Kentaro Tomii, Hiroshi Watanabe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zoological letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ivan MbogoEvolutionary Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
Chihiro KawanoEvolutionary Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
Ryotaro NakamuraEvolutionary Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
Yuko TsuchiyaArtificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan.
Alejandro Villar-BrionesInstrumental Analysis Section, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
Yoshitoshi HiraoInstrumental Analysis Section, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
Yuuri YasuokaMarine Genomics Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
Eisuke HayakawaEvolutionary Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
Kentaro TomiiArtificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan.
Hiroshi WatanabeEvolutionary Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan. Hiroshi.watanabe@oist.jp.ORCID http://orcid.org/0000-0001-8887-5407

Funding

AMED JP21am0101110Japan Society for the Promotion of Science JP19K06796Japan Society for the Promotion of Science JP20K06662Japan Society for the Promotion of Science JP22K06348
6 · The paper itself

Abstract

Beta-catenin is essential for diverse biological processes, such as body axis determination and cell differentiation, during metazoan embryonic development. Beta-catenin is thought to exert such functions through complexes formed with various proteins. Although β-catenin complex proteins have been identified in several bilaterians, little is known about the structural and functional properties of β-catenin complexes in early metazoan evolution. In the present study, we performed a comparative analysis of β-catenin sequences in nonbilaterian lineages that diverged early in metazoan evolution. We also carried out transphyletic function experiments with β-catenin from nonbilaterian metazoans using developing Xenopus embryos, including secondary axis induction in embryos and proteomic analysis of β-catenin protein complexes. Comparative functional analysis of nonbilaterian β-catenins demonstrated sequence characteristics important for β-catenin functions, and the deep origin and evolutionary conservation of the cadherin-catenin complex. Proteins that co-immunoprecipitated with β-catenin included several proteins conserved among metazoans. These data provide new insights into the conserved repertoire of β-catenin complexes.

Indexed as

MetazoanNematostella vectensisProtein complexΒ-catenin

Identifiers

PMID39623505
PMCPMC11613877

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.