Evidence map›Paper›PMID 39623312›Full record

ArticleBMC genomics2024

Expression quantitative trait loci influence DNA damage-induced apoptosis in cancer.

Jessica Bigge, Laura L Koebbe, Ann-Sophie Giel, Dorothea Bornholdt, Benedikt Buerfent, Pouria Dasmeh, Alexander M Zink, Carlo Maj, Johannes Schumacher

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jessica BiggePhilipps University of Marburg, Center for Human Genetics, Marburg, Germany.
Laura L KoebbePhilipps University of Marburg, Center for Human Genetics, Marburg, Germany.
Ann-Sophie GielPhilipps University of Marburg, Center for Human Genetics, Marburg, Germany.
Dorothea BornholdtPhilipps University of Marburg, Center for Human Genetics, Marburg, Germany.
Benedikt BuerfentPhilipps University of Marburg, Center for Human Genetics, Marburg, Germany.
Pouria DasmehPhilipps University of Marburg, Center for Human Genetics, Marburg, Germany.
Alexander M ZinkInventum Genetics GmbH, Mainz, Germany.
Carlo MajPhilipps University of Marburg, Center for Human Genetics, Marburg, Germany.
Johannes SchumacherPhilipps University of Marburg, Center for Human Genetics, Marburg, Germany. johannes.schumacher@uni-marburg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenomic instability and evading apoptosis are two fundamental hallmarks of cancer and closely linked to DNA damage response (DDR). By analyzing expression quantitative trait loci (eQTL) upon cell stimulation (called exposure eQTL (e

resultsWe isolate CD8

conclusionOur study highlights the relevance of gene regulatory variants influencing DNA damage-induced apoptosis in cancer. The results provide new insights in cellular mechanisms and corresponding genes contributing to inter-individual effects in cancer development.

Indexed as

ApoptosisDNA DamageGenome-Wide Association StudyNeoplasmsQuantitative Trait LociCD8-Positive T-LymphocytesGene Expression ProfilingHumansApoptosisCancerDNA damageeQTLGWAS

Identifiers

PMID39623312
PMCPMC11613471

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.