Evidence map›Paper›PMID 39623280›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[High expression of miR-204-5p promotes malignant behaviors of bladder cancer cells by negatively regulating RAB22A].

L Li, Y Guo, C Wang, R Chang, W Sun, W Gao, C Wang, B Liu

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
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Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

L LiDepartment of Urology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Y GuoDepartment of Urology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
C WangDepartment of Urology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
R ChangDepartment of Urology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
W SunDepartment of Urology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
W GaoDepartment of Urology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
C WangDepartment of Anesthesiology, Bozhou People's Hospital, Bozhou 236000, China.
B LiuDepartment of Urology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the regulatory effect of miR-204-5p on biological behaviors of bladder cancer cells and its molecular mechanism.

methodsSurvival analysis and correlation analysis were performed using TCGA database to explore the association of miR-204-5p expression with survival outcomes and clinicopathological parameters of bladder cancer patients. The expression level of miR-204-5p was detected in bladder cancer and adjacent tissues and in normal uroepithelial cells and bladder cancer cells. In cultured bladder cancer cells, the effects of miR-204-5p overexpression and knockdown on cell proliferation, migration, invasion, and apoptosis were analyzed. Transcriptome sequencing, bioinformatics analysis and dual-luciferase assay were carried out to confirm targeted inhibition of RAB22A by miR-204-5p to promote malignant biological behaviors of bladder cancer cells.

resultsPatients with high miR-204-5p expressions had lowered median survival time and poor prognosis (

conclusionHigh expression of miR-204-5p promotes proliferation, migration and invasion and reduces apoptosis of bladder cancer cells by negatively regulating RAB22A expression.

Indexed as

ApoptosisCell MovementCell ProliferationMicroRNAsrab GTP-Binding ProteinsUrinary Bladder NeoplasmsCell Line, TumorGene Expression Regulation, NeoplasticHumansNeoplasm InvasivenessPrognosisMicroRNAsMIRN204 microRNA, humanRAB22A protein, humanrab GTP-Binding Proteinsbladder cancermiR-204-5pRAB22A

Identifiers

PMID39623280
PMCPMC11605203

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