ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024
[Acute kidney injury after laparoscopic radical nephrectomy: role of the renin-angiotensin system and the predictive value of its activation status].
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the role of the renin-angiotensin system (RAS) in the pathogenesis of acute kidney injury (AKI) after laparoscopic radical nephrectomy (LRN) and the predictive value of RAS activation status for AKI.
methodsEighty-two patients undergoing LRN at the Third Medical Center of General Hospital of PLA from December, 2023 to March, 2024 were enrolled, including 57 with postoperative AKI and 25 without AKI according to KDIGO criteria. Blood and urine samples were collected from the patients before and at 24 h after the operation for analyzing the correlation of urinary aldosterone, plasma ACE2, Ang1-7, Nrf-2, and IL-10 levels with postoperative AKI. Univariate and multivariate logistic regression analyses and ROC curve were employed to identify the risk factors for postoperative AKI and their predictive value for AKI.
resultsCompared with those without postoperative AKI, the patients with AKI had significantly higher postoperative urinary aldosterone levels and lower plasma ACE 2, Ang 1-7, Nrf-2, and IL-10 levels (
conclusionActivation of the conventional RAS pathway and suppression of the unconventional pathway contribute to AKI following LRA possibly by affecting eGFR. Aldosterone combined with the unconventional pathway indicators can predict the occurrence of AKI after LRN.
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