Evidence map›Paper›PMID 39623275›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[E

Q Cai, H Lan, B Xian, L Liu, N Wang, X Huang, X Niu, X Hu, C Li, J Xie and 1 more

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [EstradiolZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Q CaiDepartment of Laboratory Medicine, School of Medicine, Foshan University, Foshan 528000, China.
H LanDepartment of Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
B XianDepartment of Laboratory Medicine, School of Medicine, Foshan University, Foshan 528000, China.
L LiuDepartment of Basic Medical Sciences, School of Medicine, Foshan University, Foshan 528000, China.
N WangDepartment of Laboratory Medicine, School of Medicine, Foshan University, Foshan 528000, China.
X HuangDepartment of Laboratory Medicine, School of Medicine, Foshan University, Foshan 528000, China.
X NiuDepartment of Laboratory Medicine, School of Medicine, Foshan University, Foshan 528000, China.
X HuDepartment of Laboratory Medicine, School of Medicine, Foshan University, Foshan 528000, China.
C LiDepartment of Laboratory Medicine, School of Medicine, Foshan University, Foshan 528000, China.
J XieDepartment of Laboratory Medicine, School of Medicine, Foshan University, Foshan 528000, China.
Z LiaoDepartment of Laboratory Medicine, School of Medicine, Foshan University, Foshan 528000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effect of E

methodsFemale wild-type C57BL/6 mice with and without ovariectomy and male C57BL/6 mice were given a CTX injection into the anterior tibial muscle to induce acute muscle injury, followed by intramuscular injection of β-estradiol (E

resultsCompared with the control mice, the female mice with ovariectomy showed significantly increased mononuclear macrophages in the inflammatory exudates, with increased M1 cell percentage, reduced M2 cell percentage and macrophage efferocytosis in the injured muscle, and obviously delayed myofiber regeneration and repair. In the cell co-culture systems, treatment of the myotubes with β-estradiol significantly increased the number and proportion of M2 macrophages and macrophage efferocytosis, while 4-OHT treatment resulted in the opposite changes.

conclusionIn injured mouse skeletal muscles, myofiber E

Indexed as

CardiotoxinsEstradiolMacrophagesMice, Inbred C57BLMuscle, SkeletalSignal TransductionAnimalsEfferocytosisFemaleMaleMiceMuscle Fibers, SkeletalPhagocytosisCardiotoxinsEstradiolacute skeletal muscle injuryE2 signalinginflammationmacrophages efferocytosis

Identifiers

PMID39623275
PMCPMC11605191

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.