Evidence map›Paper›PMID 39623213›Full record

ArticleScientific reports2024

Low dose Adenoviral Vammin gene transfer induces myocardial angiogenesis and increases left ventricular ejection fraction in ischemic porcine heart.

Niko Järveläinen, Paavo J Halonen, Jussi Nurro, Antti Kuivanen, Juho Pajula, Miikka Tarkia, Maria Grönman, Antti Saraste, Johanna Laakkonen, Pyry Toivanen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Niko Järveläinen *University of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences, P.O. Box 1627, 70211, Kuopio, Finland.
Paavo J Halonen *University of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences, P.O. Box 1627, 70211, Kuopio, Finland.
Jussi Nurro *University of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences, P.O. Box 1627, 70211, Kuopio, Finland.
Antti KuivanenUniversity of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences, P.O. Box 1627, 70211, Kuopio, Finland.
Juho PajulaUniversity of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences, P.O. Box 1627, 70211, Kuopio, Finland.
Miikka TarkiaUniversity of Turku, Turku PET-Center, Turku, Finland.
Maria GrönmanUniversity of Turku, Turku PET-Center, Turku, Finland.
Antti SarasteUniversity of Turku, Turku PET-Center, Turku, Finland.
Johanna LaakkonenUniversity of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences, P.O. Box 1627, 70211, Kuopio, Finland.
Pyry ToivanenUniversity of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences, P.O. Box 1627, 70211, Kuopio, Finland.
Tiina NieminenUniversity of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences, P.O. Box 1627, 70211, Kuopio, Finland.
Tuomas T RissanenUniversity of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences, P.O. Box 1627, 70211, Kuopio, Finland.
Juhani KnuutiUniversity of Turku, Turku PET-Center, Turku, Finland.
Seppo Ylä-HerttualaUniversity of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences, P.O. Box 1627, 70211, Kuopio, Finland. seppo.ylaherttuala@uef.fi.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This preliminary study investigated if VEGFR-2 selective adenoviral Vammin (AdVammin) gene therapy could induce angiogenesis and increase perfusion in the healthy porcine myocardium. Also, we determined using a clinically relevant large animal model if AdVammin gene therapy could improve the function of a chronically ischemic heart. Low doses of AdVammin (dose range 2 × 10

Indexed as

AdenoviridaeGenetic TherapyGene Transfer TechniquesMyocardial IschemiaNeovascularization, PhysiologicAngiogenesisAnimalsDisease Models, AnimalGenetic VectorsMyocardiumPositron-Emission TomographyStroke VolumeSwine

Identifiers

PMID39623213
PMCPMC11611887

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.