Evidence map›Paper›PMID 39623206›Full record

ArticleAnnals of biomedical engineering2025

A Virtual Response Surface Strategy to Predict the Effects of Contouring on the Static and Fatigue Mechanical Behavior of Spinal Rods.

Linda Carpenedo, Francesca Berti, Luigi La Barbera

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Article in Annals of biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Linda CarpenedoLaboratory of Biological Structure Mechanics (LaBS)- Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milano, Italy.
Francesca BertiLaboratory of Biological Structure Mechanics (LaBS)- Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milano, Italy. francesca.berti@polimi.it.ORCID http://orcid.org/0000-0001-8621-2503
Luigi La BarberaLaboratory of Biological Structure Mechanics (LaBS)- Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal fixation techniques based on contoured spinal rods are well established to restore an adequate sagittal alignment; however, they often break due to fatigue loading because residual stresses arise while deforming the material and they significantly reduce rod fatigue strength. The present paper aims at developing a novel strategy based on Response Surfaces (RS) as surrogate reduced order models to accurately predict the key biomechanical parameters involved both during static spinal rod contouring and subsequent fatigue loading. Finite element (FE) models of different contouring methods are performed on a wide range of spinal rods to reproduce typical clinical scenarios. RSs based on polynomial equations are initially used to fit the collected FE data and relate input parameters of the process to outputs mechanical variables. Then, the RS approach is assessed and validated by comparison with extensive experimental observations from a variety of fatigue tests. The RS provides an accurate prediction of the output parameters of interest (R

Indexed as

Models, BiologicalSpineBiomechanical PhenomenaFinite Element AnalysisHumansStress, MechanicalContouringFatigue failureFinite element analysisResidual stressResponse surfaceSpinal rod

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.