Evidence map›Paper›PMID 39623095›Full record

ArticleNature biomedical engineering2025

Concurrent intratumoural T

Yueqi Cai, Zilong Han, Jiao Shen, Zhuangzhi Zou, Jingya Guo, Yong Liang, Shijie Li, Huiping Liao, Zhenhua Ren, Hua Peng and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yueqi Cai *School of Basic Medical Sciences, Tsinghua University, Beijing, China.
Zilong Han *School of Basic Medical Sciences, Tsinghua University, Beijing, China.
Jiao ShenKey Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Zhuangzhi ZouKey Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Jingya GuoKey Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Yong LiangSchool of Basic Medical Sciences, Tsinghua University, Beijing, China.
Shijie LiSchool of Basic Medical Sciences, Tsinghua University, Beijing, China.
Huiping LiaoChangping Laboratory, Changping District, Beijing, China.
Zhenhua RenChangping Laboratory, Changping District, Beijing, China.
Hua PengKey Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. peng_hua@gzlab.ac.cn.ORCID http://orcid.org/0000-0002-2482-5475
Yang-Xin FuSchool of Basic Medical Sciences, Tsinghua University, Beijing, China. Yangxinfu@tsinghua.edu.cn.ORCID http://orcid.org/0000-0001-8441-6617

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82250710684
6 · The paper itself

Abstract

Potent agonists of the inducible co-stimulatory receptor 4-1BB are too toxic for patients with advanced cancer. Here, on the basis of observations of a weak agonist of 4-1BB depleting regulatory T (T

Indexed as

CD8-Positive T-LymphocytesInterleukin-15Lymphocyte DepletionNeoplasmsRecombinant Fusion ProteinsT-Lymphocytes, RegulatoryTumor Necrosis Factor Receptor Superfamily, Member 9AnimalsCell Line, TumorFemaleHumansMiceMice, Inbred C57BLTumor MicroenvironmentInterleukin-15Recombinant Fusion ProteinsTumor Necrosis Factor Receptor Superfamily, Member 9

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.