ArticleNature medicine2024
Hypothalamic deep brain stimulation augments walking after spinal cord injury.
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Article in Nature medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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34citing papers in PubMed, 1 pooled it
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34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of device-based neuromodulation on the motor recovery of patients with spinal cord injury.Spinal cord · 2025Pooled it
- Brain-spine interface: an exploration of a potential future treatment for spinal cord injury.Neurosurgical review · 2026Review
- Translational value of understanding brain-spinal interactions in persistent pain.Neural regeneration research · 2026Article
- Automated segmentation of neurons and spinal cord structures in immunofluorescence images using SpineDL.Scientific reports · 2026Article
- Spinal cord imaging in preclinical research.Neural regeneration research · 2026Article
- Exercise training promotes nerve cell repair and regeneration after spinal cord injury.Neural regeneration research · 2026Article
- Transforming healthcare through in-body bioelectronic systems.Nature communications · 2026Review
- Review
- Hypothalamic-superior frontal gyrus functional connectivity alterations and luteinizing hormone correlations in girls with central precocious puberty.Annals of pediatric endocrinology & metabolism · 2026Article
- Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines (2017-2025: An update) - endorsed by the European Society for Brain Stimulation (ESBS) and by the International Federation for Clinical Neurophysiology (IFCN).Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- Article
- Brain-cancer interactions outside the CNS.Oncogene · 2026Review
- Soft sonocapacitor with topologically integrated piezodielectric nanospheres enables wireless epidural closed-loop neuromodulation.Nature communications · 2026Article
- Web-based machine learning application for ambulation prognosis in the rehabilitation phase of spinal cord injury: a retrospective multicenter cohort study.Spinal cord · 2026Article
- rTMS-induced motor cortex activation drives neural network tissueoid mediated spinal motor neural pathway reconstruction.Theranostics · 2026Article
- Cuneiform Nucleus Stimulation Can Assist Gait Training to Promote Locomotor Recovery in Individuals With Incomplete Tetraplegia.Annals of neurology · 2026Article
- Emerging strategies for spinal cord injury repair: stem cells, extracellular vesicles, biomaterials, and neuromodulation.Frontiers in bioengineering and biotechnology · 2026Review
- Immediate Consequences of a Spinal Cord Injury During Development: Unique Insights From Ex Vivo Models.Neural plasticity · 2026Review
- Awakening Recovery: Enhancing Orexinergic Tone After Acute CNS Damage.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Activation of hypothalamic-pontine-spinal pathway promotes locomotor initiation and functional recovery after spinal cord injury in mice.Nature communications · 2025Article
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Authors and funding
36 authors.
Newton Cho *Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID 0000-0001-8715-611X
Jordan W Squair *Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID 0000-0003-0551-859X
Viviana AureliDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID 0000-0002-7416-621X
Nicholas D JamesDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID 0000-0001-5233-8677
Léa Bole-FeysotDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
Inssia DewanyDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID 0000-0001-9544-4285
Nicolas HankovDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
Laetitia BaudDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID 0000-0001-7531-0036
Anna LeonhartsbergerDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
Kristina SveistyteDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
Michael A SkinniderLewis-Sigler Institute of Integrative Genomics and Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-2168-1621
Matthieu GautierDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID 0000-0003-4910-8576
Achilleas LaskaratosDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID 0000-0002-2456-5781
Katia GalanDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
Maged GoubranDepartment of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-5880-0818
Jimmy RavierDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
Frederic MerlosDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
Laura BattiWyss Center for Bio and Neuroengineering, Geneva, Switzerland.
Stéphane PagesWyss Center for Bio and Neuroengineering, Geneva, Switzerland.
Nadia BerardDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID 0000-0002-2082-4221
Nadine InteringDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID 0000-0003-1741-2178
Camille VaresconDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
Anne WatrinONWARD Medical, Lausanne, Switzerland.
Léa DuguetONWARD Medical, Lausanne, Switzerland.
Stefano CardaDepartment of Clinical Neuroscience, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Kay A BartholdiDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
Thomas H HutsonDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID 0000-0001-6795-2688
Claudia KatheDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID 0000-0001-6441-1755
Michael HodaraDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
Mark A AndersonDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID 0000-0003-1855-6106
Bogdan DraganskiDepartment of Clinical Neuroscience, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID 0000-0002-5159-5919
Robin DemesmaekerDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID 0000-0003-0856-0929
Leonie AsbothDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
Quentin BarraudDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID 0000-0003-0894-1959
Jocelyne BlochDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland. jocelyne.bloch@chuv.ch.ORCID 0000-0002-6405-1590
Grégoire CourtineDefitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland. gregoire.courtine@epfl.ch.ORCID 0000-0002-5744-4142
Funding
EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 682999Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) Research fellowship award to Newton ChoHuman Frontier Science Program (HFSP) LT001278/2017-LSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 310030_185214Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 310030_215668Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) PZ00P3_208988
Abstract
A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after incomplete SCI and that could be targeted to augment this recovery. To uncover these regions, we constructed a space-time brain-wide atlas of transcriptionally active and spinal cord-projecting neurons underlying the recovery of walking after incomplete SCI. Unexpectedly, interrogation of this atlas nominated the lateral hypothalamus (LH). We demonstrate that glutamatergic neurons located in the LH (LH
Indexed as
Deep Brain StimulationNeuronsSpinal Cord InjuriesWalkingAdultAnimalsFemaleHumansHypothalamic Area, LateralHypothalamusMaleMiceMiddle AgedPilot ProjectsRatsRecovery of Function
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.