Evidence map›Paper›PMID 39623068›Full record

ArticleNature microbiology2025

Influenza A(H5N1) shedding in air corresponds to transmissibility in mammals.

Ilona I Tosheva, Fabien Filaire, Willemijn F Rijnink, Dennis de Meulder, Bianca van Kekem, Theo M Bestebroer, Mathis Funk, Monique I Spronken, C Joaquin Cáceres, Daniel R Perez and 5 more

Abstract read
In one paragraph

Article in Nature microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. The emergence of highly pathogenic avian influenza H5N1 in dairy cattle: implications for public health, animal health, and pandemic preparedness.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ilona I ToshevaDepartment of Viroscience, Erasmus University Medical Centre, Rotterdam, the Netherlands.
Fabien FilaireDepartment of Viroscience, Erasmus University Medical Centre, Rotterdam, the Netherlands.
Willemijn F RijninkDepartment of Viroscience, Erasmus University Medical Centre, Rotterdam, the Netherlands.
Dennis de MeulderDepartment of Viroscience, Erasmus University Medical Centre, Rotterdam, the Netherlands.
Bianca van KekemDepartment of Viroscience, Erasmus University Medical Centre, Rotterdam, the Netherlands.
Theo M BestebroerDepartment of Viroscience, Erasmus University Medical Centre, Rotterdam, the Netherlands.
Mathis FunkDepartment of Viroscience, Erasmus University Medical Centre, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0001-7830-9989
Monique I SpronkenDepartment of Viroscience, Erasmus University Medical Centre, Rotterdam, the Netherlands.
C Joaquin CáceresDepartment of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.ORCID http://orcid.org/0000-0001-8508-6592
Daniel R PerezDepartment of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.ORCID http://orcid.org/0000-0002-6569-5689
Mathilde RichardDepartment of Viroscience, Erasmus University Medical Centre, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-0240-9312
Marion P G KoopmansDepartment of Viroscience, Erasmus University Medical Centre, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-5204-2312
Pieter L A FraaijDepartment of Viroscience, Erasmus University Medical Centre, Rotterdam, the Netherlands.
Ron A M FouchierDepartment of Viroscience, Erasmus University Medical Centre, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0001-8095-2869
Sander HerfstDepartment of Viroscience, Erasmus University Medical Centre, Rotterdam, the Netherlands. s.herfst@erasmusmc.nl.ORCID http://orcid.org/0000-0001-9866-8903

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research) 09150182110054
6 · The paper itself

Abstract

An increase in spillover events of highly pathogenic avian influenza A(H5N1) viruses to mammals suggests selection of viruses that transmit well in mammals. Here we use air-sampling devices to continuously sample infectious influenza viruses expelled by experimentally infected ferrets. The resulting quantitative virus shedding kinetics data resembled ferret-to-ferret transmission studies and indicated that the absence of transmission observed for earlier A(H5N1) viruses was due to a lack of infectious virus shedding in the air, rather than the absence of necessary mammalian adaptation mutations. Whereas infectious human A(H1N1

Indexed as

Air MicrobiologyInfluenza A Virus, H5N1 SubtypeOrthomyxoviridae InfectionsVirus SheddingAnimalsCattleFerretsHumansInfluenza A Virus, H1N1 SubtypeInfluenza, HumanMammals

Identifiers

PMID39623068
PMCPMC11726459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.