Evidence map›Paper›PMID 39623043›Full record

ArticleActa pharmacologica Sinica2025

Nicotinamide mononucleotide protects septic hearts in mice via preventing cyclophilin F modification and lysosomal dysfunction.

Rui Ni, Xiao-Yun Ji, Ting Cao, Xiu-Wen Liu, Chao Wang, Chao Lu, Angel Peng, Zhu-Xu Zhang, Guo-Chang Fan, Jin Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmacologica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rui Ni *International Genome Center, Jiangsu University, Zhenjiang, 212013, China.
Xiao-Yun Ji *International Genome Center, Jiangsu University, Zhenjiang, 212013, China.
Ting Cao *Institutes of Biology and Medical Sciences and Institute for Cardiovascular Science, Soochow University, Suzhou, 215123, China.
Xiu-Wen LiuAffiliated Hospital, Jiangsu University, Zhenjiang, 212013, China.
Chao WangInternational Genome Center, Jiangsu University, Zhenjiang, 212013, China.
Chao LuDepartment of Chemical and Biochemical Engineering, Western University, London, ON, Canada.
Angel PengDepartment of Pathology and Laboratory Medicine, Western University, London, ON, Canada.
Zhu-Xu ZhangDepartment of Pathology and Laboratory Medicine, Western University, London, ON, Canada.
Guo-Chang FanDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Jin ZhangDepartment of Chemical and Biochemical Engineering, Western University, London, ON, Canada.
Zhao-Liang SuInternational Genome Center, Jiangsu University, Zhenjiang, 212013, China. szl30@ujs.edu.cn.
Tian-Qing PengDepartment of Pathology and Laboratory Medicine, Western University, London, ON, Canada. tpeng2@uwo.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial dysfunction is a decisive factor of death in septic patients. Cyclophilin F (PPIF) is a major component of the mitochondrial permeability transition pore (mPTP) and acts as a critical mPTP sensitizer triggering mPTP opening. In sepsis, decreased NAD

Indexed as

LysosomesMice, Inbred C57BLMitochondrial Permeability Transition PoreNicotinamide MononucleotidePeptidyl-Prolyl Isomerase FSepsisAnimalsAutophagyCardiotonic AgentsCyclophilinsLipopolysaccharidesMaleMiceMitochondria, HeartMyocardiumMyocytes, CardiacCardiotonic AgentsCyclophilinsLipopolysaccharidesMitochondrial Permeability Transition PoreNicotinamide MononucleotidePeptidyl-Prolyl Isomerase FPPIF protein, mouseReactive Oxygen Speciescyclophilin FLPSMito-TEMPOmyocardial dysfunctionnicotinamide mononucleotidesepsis

Identifiers

PMID39623043
PMCPMC11950505

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.