ArticleCommunications biology2024
Left atrial single-cell transcriptomics reveals amphiregulin as a surrogate marker for atrial fibrillation.
Erratum issuedAbstract read
In one paragraph
Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Freely available genomic datasets for atrial fibrillation research: current resources and analytical pipeline.Frontiers in genetics · 2026Pooled it
- Understanding the Diseased Atria.Physiology (Bethesda, Md.) · 2026Review
- Gut microbiota-activated PLCγ2 monocytes drive atrial fibrillation.Nature communications · 2026Article
- Cardiac Macrophages and Fibroblasts Modulate Atrial Fibrillation Maintenance.Circulation research · 2026Article
- PVN-centered multi-omics and single-cell analyses suggest shared inflammatory and immune features in acute myocardial infarction-associated ventricular arrhythmia and atrial fibrillation.Frontiers in cardiovascular medicine · 2026Article
- Metabolic and Inflammatory Mechanisms Driving Atrial Fibrillation.Annual review of pharmacology and toxicology · 2026Review
- Single-cell transcriptomic insights into the intrinsic cardiac nervous system: diversity, development, and neuro-cardiac interactions.Frontiers in genetics · 2026Review
- Immune Cell Dynamics in Cardiac Diseases: Insights From Single-Cell Sequencing.Journal of cellular and molecular medicine · 2025Review
- Amphiregulin in Fibrotic Diseases and Cancer.International journal of molecular sciences · 2025Review
Corrections and comments
- Erratum issued
Authors and funding
34 authors.
Yuya SuzukiDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.ORCID 0000-0002-6790-0914
Takuo EmotoDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan. emotot@med.kobe-u.ac.jp.ORCID 0000-0001-7425-4087
Shunsuke SatoDivision of Cardiovascular Surgery, Department of Surgery, Yodogawa Christian Hospital, Osaka, Japan.
Takeshi YoshidaDepartment of Information and Intelligence Engineering, Kobe University, Kobe, Japan.
Mitsuhiko ShodaDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Hiromi EndohDivision of Structural Medicine and Anatomy, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Manabu NagaoDivision of Evidence-Based Laboratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.ORCID 0000-0001-7269-4513
Tomoyo HamanaDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Taishi InoueDivision of Cardiovascular Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Tomohiro HayashiDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.ORCID 0000-0002-0164-7629
Eriko NittaDivision of Structural Medicine and Anatomy, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Hiroki KonishiDivision of Cardiovascular Medicine, Department of Internal Medicine, Yodogawa Christian Hospital, Osaka, Japan.
Kunihiko KiuchiDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.ORCID 0000-0002-9305-4854
Mitsuru TakamiDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Kimitake ImamuraDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Masayuki TaniguchiDivision of Pharmacology, Kobe University Graduate School of Medicine, Kobe, Japan.
Masatoshi InoueDepartment of Information and Intelligence Engineering, Kobe University, Kobe, Japan.
Toshihiro NakamuraDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Yusuke SonodaDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Hiroyuki TakaharaDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Kazutaka NakasoneDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Kyoko YamamotoDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Kenichi TaniDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Hidehiro IwaiDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Yusuke NakanishiDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Shogo YoneharaDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Atsushi MurakamiDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Ryuji TohDivision of Evidence-Based Laboratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Takenao OhkawaDepartment of Information and Intelligence Engineering, Kobe University, Kobe, Japan.
Tomoyuki FuruyashikiDivision of Pharmacology, Kobe University Graduate School of Medicine, Kobe, Japan.ORCID 0000-0001-8089-8399
Ryo NittaDivision of Structural Medicine and Anatomy, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan.ORCID 0000-0002-6537-9272
Tomoya YamashitaDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.ORCID 0000-0003-0267-3842
Ken-Ichi HirataDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Koji FukuzawaDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Funding
Japan Agency for Medical Research and Development (AMED) 18069370Japan Agency for Medical Research and Development (AMED) JP21gm0910012Japan Agency for Medical Research and Development (AMED) JP21wm0425001MEXT | Japan Society for the Promotion of Science (JSPS) 18H05429MEXT | Japan Society for the Promotion of Science (JSPS) 19H03653MEXT | Japan Society for the Promotion of Science (JSPS) 20H03676MEXT | Japan Society for the Promotion of Science (JSPS) 20K21603MEXT | Japan Society for the Promotion of Science (JSPS) 21H04812MEXT | Japan Society for the Promotion of Science (JSPS) 21H05254MEXT | Japan Society for the Promotion of Science (JSPS) 22K08206MEXT | Japan Society for the Promotion of Science (JSPS) 22K16105
Abstract
Atrial fibrillation (AF) is strongly associated with strokes, heart failure, and increased mortality. This study aims to identify the monocyte-macrophage heterogeneity and interactions of these cells with non-immune cells, and to identify functional biomarkers in patients with AF. Therefore, we assess the single cell landscape of left atria (LA), using a combination of single cell and nucleus RNA-seq. Myeloid cells in LA tissue are categorized into five macrophage clusters, three monocyte clusters, and others. Cell-Chat analysis revealed that monocytes and IL1B
Indexed as
AmphiregulinAtrial FibrillationBiomarkersHeart AtriaSingle-Cell AnalysisTranscriptomeAgedFemaleGene Expression ProfilingHumansMacrophagesMaleMiddle AgedMonocytesAmphiregulinAREG protein, humanBiomarkers
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.