Evidence map›Paper›PMID 39622450›Full record

ArticleResuscitation2025

Impact of coma duration on functional outcomes at discharge and long-term survival after cardiac arrest.

Jonathan Tam, Nicholas Case, Patrick Coppler, Clifton Callaway, Laura Faiver, Jonathan Elmer, University of Pittsburgh Post-Cardiac Arrest Service

Abstract read
In one paragraph

Article in Resuscitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jonathan TamDepartment of Emergency Medicine, University of Pittsburgh, School of Medicine, USA; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, USA. Electronic address: tamjw@upmc.edu.
Nicholas CaseDepartment of Emergency Medicine, University of Pittsburgh, School of Medicine, USA.
Patrick CopplerDepartment of Emergency Medicine, University of Pittsburgh, School of Medicine, USA.
Clifton CallawayDepartment of Emergency Medicine, University of Pittsburgh, School of Medicine, USA.
Laura FaiverDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, USA.
Jonathan ElmerDepartment of Emergency Medicine, University of Pittsburgh, School of Medicine, USA; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, USA; Department of Neurology, University of Pittsburgh, School of Medicine, USA.
University of Pittsburgh Post-Cardiac Arrest Service

Funding

PREcision Care In Cardiac ArrEst - ICECAP (PRECICECAP)R01NS119825 · NINDS · STANFORD UNIVERSITY · PI ELMER, JONATHAN, HIRSCH, KAREN G · 2021 to 2025
$7.0M
Multidisciplinary Training in Critical Care Outcomes ResearchT32HL007820 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Timothy D Girard, Jeremy M Kahn · 1996 to 2026
$6.4M
Emergency Medicine Research TrainingT32HL134615 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Clifton W. Callaway, DONALD M YEALY · 2017 to 2026
$2.4M
NHLBI NIH HHS T32 HL007820NHLBI NIH HHS T32 HL134615NINDS NIH HHS R01 NS119825
6 · The paper itself

Abstract

introductionAwakening from coma is crucial for survivors of cardiac arrest, though coma duration is variable. We tested the association of coma duration with short-term functional recovery and long-term survival after cardiac arrest.

methodsIn this retrospective cohort study, we identified post-arrest patients who were comatose on presentation but awakened during hospitalization. We recorded demographics, arrest characteristics, days from arrest to awakening, and modified Rankin Scale (mRS) at hospital discharge. We compared discharge mRS between patients with short and long coma duration dichotomized at its median, 3, and 6 days. We compared long-term survival between patients with short and long coma duration who survived to hospital discharge. Finally, we used Cox regression to quantify the independent association of coma duration with survival after adjusting for patient and arrest characteristics.

resultsWe included 979 subjects with median coma duration 2 [IQR 1-4] days. Shorter coma duration was associated with a higher proportion of patients with discharge mRS ≤ 3 (p < 0.001). We observed 742 subjects who survived to discharge for 3,136 person-years and found no difference in long-term survival between short and long coma durations (p = 0.86). Coma duration was not associated with hazard of death (HR 1.00, 95 %CI 0.97-1.03) after adjusting for age, location of arrest, Charlson Comorbidity Index, and discharge mRS.

conclusionsShorter coma duration was associated with better functional outcome at discharge, but not with long-term survival.

Indexed as

ComaHeart ArrestPatient DischargeAgedCardiopulmonary ResuscitationFemaleHumansMaleMiddle AgedRecovery of FunctionRetrospective StudiesTime FactorsCardiac arrestComaOutcomesSurvival

Identifiers

PMID39622450
PMCPMC12668263

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.