ArticleProgress in neurobiology2024
Prefrontal excitation/inhibition balance supports adolescent enhancements in circuit signal to noise ratio.
Article in Progress in neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Age-Related Differences in Corticospinal Function and Muscle Strength: A Systematic Review and Meta-Analysis.The European journal of neuroscience · 2026Pooled it
- Developmental and aging trajectories of 40-Hz auditory steady-state responses: A systematic review across the human lifespan.Developmental cognitive neuroscience · 2026Pooled it
- Gut microbiota remodeling and sensory-emotional functional disruption in adolescents with bipolar depression.Journal of translational medicine · 2025Trial
- Prefrontal Circuitry Abnormalities and Cognitive Impairment in Adolescents with Early- Onset Psychosis.Research square · 2026Article
- Aperiodic Signatures of Stress Sensitivity and Depression Recurrence in Adolescents.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Adolescent and adult stress alter excitatory-inhibitory network dynamics in the medial prefrontal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- APOE4 and doxorubicin impair inhibitory interneuron function and homeostatic regulation in the entorhinal cortex.PloS one · 2026Article
- Investigating hierarchical critical periods in human neurodevelopment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Altered Bilateral Motor Cortex Excitability and Peripheral Glutamate/GABA Imbalance in Generalized Anxiety Disorder: A TMS Investigation.Psychology research and behavior management · 2026Article
- Cross-species evidence for the refinement of intrinsic neural timescales supporting executive system maturation through adolescence.bioRxiv : the preprint server for biology · 2025Article
- Developmental decorrelation of local cortical activity through adolescence supports high-dimensional encoding and working memory.Developmental cognitive neuroscience · 2025Article
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7 authors.
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Abstract
The development and refinement of neuronal circuitry allow for stabilized and efficient neural recruitment, supporting adult-like behavioral performance. During adolescence, the maturation of PFC is proposed to be a critical period (CP) for executive function, driven by a break in balance between glutamatergic excitation and GABAergic inhibition (E/I) neurotransmission. During CPs, cortical circuitry fine-tunes to improve information processing and reliable responses to stimuli, shifting from spontaneous to evoked activity, enhancing the SNR, and promoting neural synchronization. Harnessing 7 T MR spectroscopy and EEG in a longitudinal cohort (N = 164, ages 10-32 years, 283 neuroimaging sessions), we outline associations between age-related changes in glutamate and GABA neurotransmitters and EEG measures of cortical SNR. We find developmental decreases in spontaneous activity and increases in cortical SNR during our auditory steady state task using 40 Hz stimuli. Decreases in spontaneous activity were associated with glutamate levels in DLPFC, while increases in cortical SNR were associated with more balanced Glu and GABA levels. These changes were associated with improvements in working memory performance. This study provides evidence of CP plasticity in the human PFC during adolescence, leading to stabilized circuitry that allows for the optimal recruitment and integration of multisensory input, resulting in improved executive function.
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