Evidence map›Paper›PMID 39621999›Full record

ArticleInorganic chemistry2024

Disulfide-Bridged Cationic Dinuclear Ir(III) Complex with Aggregation-Induced Emission and Glutathione-Consumption Properties for Elevating Photodynamic Therapy.

Meijia Huang, Jie Cui, Qi Wu, Shengnan Liu, Dongxia Zhu, Guangzhe Li, Martin R Bryce, Dong Wang, Ben Zhong Tang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inorganic chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Meijia HuangKey Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin Province 130024, P. R. China.
Jie CuiCenter for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.
Qi WuKey Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin Province 130024, P. R. China.
Shengnan LiuKey Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin Province 130024, P. R. China.
Dongxia ZhuKey Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin Province 130024, P. R. China.ORCID 0000-0003-3002-0144
Guangzhe LiJilin Provincial Science and Technology Innovation Center of Health Food of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province 130117, P. R. China.
Martin R BryceDepartment of Chemistry, Durham University, Durham DH1 3LE, U.K.ORCID 0000-0003-2097-7823
Dong WangCenter for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0000-0001-5137-0771
Ben Zhong TangCenter for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0000-0002-0293-964X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability of photosensitizers (PSs) to generate reactive oxygen species (ROS) is crucial for photodynamic therapy (PDT). However, many traditional PSs face the drawbacks that aggregation-caused quenching (ACQ) and highly expressed glutathione (GSH) in the tumor microenvironment seriously limit their ROS generation ability. Herein, we report two cationic dinuclear iridium complexes,

Indexed as

Coordination ComplexesDisulfidesGlutathioneIridiumPhotochemotherapyPhotosensitizing AgentsAntineoplastic AgentsCationsCell SurvivalDrug Screening Assays, AntitumorHumansMolecular StructureReactive Oxygen SpeciesSinglet OxygenAntineoplastic AgentsCationsCoordination ComplexesDisulfidesGlutathioneIridiumPhotosensitizing AgentsReactive Oxygen SpeciesSinglet Oxygen

Identifiers

PMID39621999
PMCPMC11653252

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.