ArticleProceedings of the National Academy of Sciences of the United States of America2024
Prenatal social disadvantage is associated with alterations in functional networks at birth.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Pregnancy diet based on ancestral patterns increases growth in subcortical fetal brain regions.Proceedings of the National Academy of Sciences of the United States of America · 2026Trial
- Functional brain connectivity from the fetal period through infancy: A narrative review of resting-state fMRI studies.Developmental cognitive neuroscience · 2026Review
- Environmental roots of neonatal health: how social and structural exposures shape early-life outcomes.Pediatric research · 2026Review
- Social Determinants of Health, the developing brain, and risk and resilience for psychopathology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Age-related patterns of resting EEG power in infancy: Associations with prenatal socioeconomic disadvantage.Developmental cognitive neuroscience · 2025Article
- Social Determinants of Health and Early Brain Development.Pediatric clinics of North America · 2025Review
- Prenatal social disadvantage is associated with alterations in functional networks at birth.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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Authors and funding
24 authors.
Funding
Abstract
Childhood exposure to social disadvantage is a major risk factor for psychiatric disorders and poor developmental, educational, and occupational outcomes, presumably because adverse exposures alter the neurodevelopmental processes that contribute to risk trajectories. Yet, given the limited social mobility in the United States and other countries, childhood social disadvantage is frequently preceded by maternal social disadvantage during pregnancy, potentially altering fetal brain development during a period of high neuroplasticity through hormonal, microbiome, epigenetic, and immune factors that cross the placenta and fetal blood-brain barrier. The current study examines prenatal social disadvantage to determine whether these exposures in utero are associated with alterations in functional brain networks as early as birth. As part of the Early Life Adversity and Biological Embedding study, mothers were recruited during pregnancy, prenatal social disadvantage was assessed across trimesters, and their healthy, full-term offspring were imaged using resting-state functional magnetic resonance imaging during the first weeks of life. Multivariate machine learning methods revealed that neonatal functional connectivity (FC) varied as a function of prenatal exposure to social disadvantage (n = 261, R = 0.43, R
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