ArticlePLoS biology2024
The thalamus encodes and updates context representations during hierarchical cognitive control.
Article in PLoS biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Network Mechanisms of Cognitive Control
Investigating Mediodorsal Thalamus Representations Underlying Human Cognitive Flexibility
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sleep disorders and structural alterations in brain regions linked with motivation: a neuroimaging meta-analysis.Scientific reports · 2026Pooled it
- A large-scale heterogeneous 3D magnetic resonance brain imaging dataset for self-supervised learning.Scientific data · 2026Article
- Hierarchical Reconfiguration of Neurocognitive Task Set Representations Mediates Cognitive Flexibility.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Cortical functional hierarchy disruption following subcortical stroke.BMC medicine · 2026Article
- Hierarchical Reconfiguration of Neurocognitive Task Set Representations Mediates Cognitive Flexibility.bioRxiv : the preprint server for biology · 2026Article
- Frontoparietal Hubs Leverage Probabilistic Representations and Integrated Uncertainty to Guide Cognitive Flexibility.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Frontoparietal Hubs Leverage Probabilistic Representations and Integrated Uncertainty to Guide Cognitive Flexibility.bioRxiv : the preprint server for biology · 2025Article
- Thalamic volume alterations mediate glymphatic function and cognitive dysfunction in Alzheimer's disease.Alzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
5 authors.
Funding
Abstract
Cognitive flexibility relies on hierarchically structured task representations that organize task contexts, relevant environmental features, and subordinate decisions. Despite ongoing interest in the human thalamus, its role in cognitive control has been understudied. This study explored thalamic representation and thalamocortical interactions that contribute to hierarchical cognitive control in humans. We found that several thalamic nuclei, including the anterior, mediodorsal, ventrolateral, and pulvinar nuclei, exhibited stronger evoked responses when subjects switch between task contexts. Decoding analysis revealed that thalamic activity encodes task contexts within the hierarchical task representations. To determine how thalamocortical interactions contribute to task representations, we developed a thalamocortical functional interaction model to predict task-related cortical representation. This data-driven model outperformed comparison models, particularly in predicting activity patterns in cortical regions that encode context representations. Collectively, our findings highlight the significant contribution of thalamic activity and thalamocortical interactions for contextually guided hierarchical cognitive control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.