Evidence map›Paper›PMID 39621528›Full record

ArticleFEBS open bio2025

Potential radiosensitive germline biomarkers in the testes of wild mice after the Fukushima accident.

Syun Tokita, Ryo Nakayama, Yohei Fujishima, Valerie Swee Ting Goh, Donovan Anderson, Ippei Uemura, Hikari Ikema, Jin Shibata, Yoh Kinoshita, Yoshinaka Shimizu and 9 more

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In one paragraph

Article in FEBS open bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Syun TokitaGraduate School of Science and Technology, Niigata University, Japan.
Ryo NakayamaDepartment of Risk Analysis and Biodosimetry, Institute of Radiation Emergency Medicine, Hirosaki University, Aomori, Japan.
Yohei FujishimaDepartment of Risk Analysis and Biodosimetry, Institute of Radiation Emergency Medicine, Hirosaki University, Aomori, Japan.
Valerie Swee Ting GohDepartment of Radiobiology, Singapore Nuclear Research and Safety Initiative, National University of Singapore, Singapore.
Donovan AndersonDepartment of Risk Analysis and Biodosimetry, Institute of Radiation Emergency Medicine, Hirosaki University, Aomori, Japan.ORCID https://orcid.org/0000-0001-6716-4059
Ippei UemuraFaculty of Pharmaceutical Sciences, Hokkaido University of Science, Sapporo, Japan.ORCID https://orcid.org/0009-0002-9457-3127
Hikari IkemaGraduate School of Science and Technology, Niigata University, Japan.
Jin ShibataGraduate School of Science and Technology, Niigata University, Japan.
Yoh KinoshitaGraduate School of Science and Technology, Niigata University, Japan.
Yoshinaka ShimizuGraduate School of Dentistry, Tohoku University, Sendai, Japan.
Hisashi ShinodaGraduate School of Dentistry, Tohoku University, Sendai, Japan.
Jun GotoInstitute for Research Administration, Niigata University, Japan.ORCID https://orcid.org/0000-0001-5135-4587
Maria Grazia PalmeriniDepartment of Life, Health and Environmental Sciences, University of L'Aquila, Italy.ORCID https://orcid.org/0000-0002-3985-0112
Abdulla Mohamed HathaDepartment of Marine Biology, Microbiology, Biochemistry, Cochin University of Science and Technology, India.
Takashi SatohFaculty of Pharmaceutical Sciences, Hokkaido University of Science, Sapporo, Japan.ORCID https://orcid.org/0000-0002-6097-948X
Akifumi NakataFaculty of Pharmaceutical Sciences, Hokkaido University of Science, Sapporo, Japan.ORCID https://orcid.org/0000-0002-8728-1655
Manabu FukumotoRIKEN Centre for Advanced Intelligence Project, Pathology Informatics Team, Tokyo, Japan.
Tomisato MiuraDepartment of Risk Analysis and Biodosimetry, Institute of Radiation Emergency Medicine, Hirosaki University, Aomori, Japan.ORCID https://orcid.org/0000-0003-3104-2134
Hideaki YamashiroGraduate School of Science and Technology, Niigata University, Japan.ORCID https://orcid.org/0000-0002-0133-2459

Funding

Environmental Radioactivity Research Network Center of Hirosaki and Tsukuba University F23-31Japan Society for the Promotion of Science 19KK0176Japan Society for the Promotion of Science 20K12192Sasakawa Scientific Research Grant from the Japan Science Society 2022-5026
6 · The paper itself

Abstract

We investigated potential germline-specific radiosensitive biomarkers in the testes of large Japanese field mice (Apodemus speciosus) exposed to low-dose-rate (LDR) radiation after the Fukushima accident. Fukushima wild mice testes were analysed via RNA-sequencing to identify genes differentially expressed in the breeding and non-breeding seasons when compared to controls. Results revealed significant changes during the breeding season, with Lsp1 showing a considerable upregulation, while Ptprk and Tspear exhibited significant reductions. Conversely, in the non-breeding season, Fmo2 and Fmo2 (highly similar) were significantly upregulated in radiation-exposed Fukushima mice. qPCR analysis results were consistent with transcriptome sequencing, detecting Lsp1 and Ptprk regulation in the testes of Fukushima mice. While differences in gene expression were observed, these do not imply any causal association between the identified biomarkers and chronic LDR exposure, as other factors such as the environment and developmental age may contribute. This study provides valuable insights into the reproductive biology is affected by environmental radiation and highlights the value of assessing the effects of chronic LDR radiation exposure on testicular health in wild mice.

Indexed as

Fukushima Nuclear AccidentGerm CellsRadiation ToleranceTestisAnimalsBiomarkersMaleMiceMurinaeTranscriptomeBiomarkersApodemus speciosusFukushima accidentlow‐dose‐rate radiationradiosensitive biomarkers

Identifiers

PMID39621528
PMCPMC11788752

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.