Evidence map›Paper›PMID 39621449›Full record

ArticleThe Journal of physiology2025

Displacement of extracellular chloride by immobile anionic constituents of the brain's extracellular matrix.

Kieran P Normoyle, Kyle P Lillis, Kiyoshi Egawa, Melanie A McNally, Mousumi Paulchakrabarti, Biswa P Coudhury, Lauren Lau, Fu Hung Shiu, Kevin J Staley

Abstract read
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kieran P NormoyleDepartment of Neurology, Division of Child Neurology, Massachusetts General Hospital, Boston, MA, USA.
Kyle P LillisDepartment of Neurology, Division of Child Neurology, Massachusetts General Hospital, Boston, MA, USA.
Kiyoshi EgawaDepartment of Medicine, Hokaiddo University, Sapporo, Hokaiddo, Japan.
Melanie A McNallyDepartment of Neurology, Division of Child Neurology, Massachusetts General Hospital, Boston, MA, USA.
Mousumi PaulchakrabartiGlycoAnalytics Core, University of California San Diego, La Jolla, CA, USA.
Biswa P CoudhuryGlycoAnalytics Core, University of California San Diego, La Jolla, CA, USA.
Lauren LauDepartment of Neurology, Division of Child Neurology, Massachusetts General Hospital, Boston, MA, USA.
Fu Hung ShiuDepartment of Neurology, Division of Child Neurology, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-2658-6778
Kevin J StaleyDepartment of Neurology, Division of Child Neurology, Massachusetts General Hospital, Boston, MA, USA.

Funding

Neuronal Ion and Volume Shifts After Acute Brain InjuryR35NS116852 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Kevin J. Staley · 2020 to 2026
$8.0M
Neuronal Chloride distribution by displacementR01NS040109 · NINDS · UNIVERSITY OF COLORADO DENVER · PI STALEY, KEVIN J. · 2000 to 2020
$7.2M
Multiphoton In Vivo Microscopy (Core 2)P01NS127769 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Kevin J. Staley · 2023 to 2026
$6.5M
NINDS NIH HHS P01 NS127769NINDS NIH HHS R01 NS040109NINDS NIH HHS R35 NS116852
6 · The paper itself

Abstract

GABA is the primary inhibitory neurotransmitter. Membrane currents evoked by GABA

Indexed as

BrainChloridesExtracellular MatrixAnimalsAnionsGlycosaminoglycansMembrane PotentialsMiceReceptors, GABA-AAnionsChloridesGlycosaminoglycansReceptors, GABA-Achloridechloride currentepilepsyextracellular chlorideextracellular matrixGABA receptorimmobile anions

Identifiers

PMID39621449
PMCPMC11747837

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.