Evidence map›Paper›PMID 39621311›Full record

ArticleThe Journal of clinical investigation2024

Therapeutic hypoxia for mitochondrial disease via enhancement of hemoglobin affinity and inhibition of HIF-2α.

Hong Wang, Maria Miranda, Eizo Marutani, Paul Lichtenegger, Gregory R Wojtkiewicz, Fumito Ichinose, Vamsi K Mootha

Abstract read
In one paragraph

Article in The Journal of clinical investigation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Power and poison: The intersections of HThe Journal of biological chemistry · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Hypoxia as a medicine.Science translational medicine · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hong WangHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Maria MirandaHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Eizo MarutaniAnesthesia Center for Critical Care Research and.
Paul LichteneggerAnesthesia Center for Critical Care Research and.
Gregory R WojtkiewiczCenter for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Fumito IchinoseAnesthesia Center for Critical Care Research and.
Vamsi K MoothaHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Funding

Preventing and Reversing Mitochondrial Leigh Syndrome with HypoxiaR01NS124679 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Vamsi Krishna Mootha · 2022 to 2026
$2.6M
NINDS NIH HHS R01 NS124679
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

GeneticsHypoxia

Identifiers

PMID39621311
PMCPMC11601899

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.