Evidence map›Paper›PMID 39621232›Full record

ArticleMolecular neurobiology2025

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Guojing Lu, Rong Huang, Siyu Zeng, Yiqiao Xing, Hang Xie, Lei Du

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Guojing Lu *Eye Center, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, Hubei Province, People's Republic of China.ORCID http://orcid.org/0009-0008-6116-8225
Rong HuangEye Center, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, Hubei Province, People's Republic of China.ORCID http://orcid.org/0009-0009-3309-6567
Siyu ZengEye Center, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, Hubei Province, People's Republic of China.ORCID http://orcid.org/0000-0003-2797-9653
Yiqiao XingEye Center, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, Hubei Province, People's Republic of China.ORCID http://orcid.org/0000-0001-5534-1951
Hang XieEye Center, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, Hubei Province, People's Republic of China.ORCID http://orcid.org/0009-0006-6585-536X
Lei Du *Eye Center, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, Hubei Province, People's Republic of China. du_lei@whu.edu.cn.ORCID http://orcid.org/0000-0002-4434-6586

Funding

Fundamental Research Funds for the Central Universities 2042022kf1087National Natural Science Foundation of China Grant No. 82401285
6 · The paper itself

Abstract

Retinal ischemia-reperfusion injury (RIRI) is a pathological process that occurs in various blinding eye diseases and is often accompanied by anxiety and depression. However, the underlying metabolic mechanism of mood disorders remains unclear. This study aimed to investigate the metabolic dynamics of the brain after RIRI. C57BL/6 J mice were used to establish the RIRI model and assessed after 1 and 7 days. Mood-related behaviors were examined using open-field, elevated plus-maze, and forced swimming tests. Retinal injury histology was assessed using retinal hematoxylin and eosin staining. Retinal apoptosis was measured via the TdT-mediated dUTP nick-end labeling staining. The

Indexed as

BrainBrain ChemistryReperfusion InjuryRetinaAnimalsAnxietyApoptosisBehavior, AnimalGlutamic AcidKineticsMagnetic Resonance SpectroscopyMaleMiceMice, Inbred C57BLGlutamic Acid[1H-13C]-NMREye-brain connectionGln/Glu-GABA cycleMood disordersRetinal ischemia-reperfusion injury

Identifiers

PMID39621232

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.