Evidence map›Paper›PMID 39621187›Full record

ArticlePediatric surgery international2024

Yes-associated protein is dysregulated in human congenital diaphragmatic hernia patients during mid and end gestation.

Yuichiro Miyake, Marietta Jank, Daywin Patel, Arzu Ozturk, Ophelia Aubert, Xingbin Ai, Atsuyuki Yamataka, Richard Keijzer

Abstract read
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Article in Pediatric surgery international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Mechanical compression causes lung hypoplasia in congenital diaphragmatic hernia with GATA4 genetic variants.American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuichiro MiyakeDivision of Pediatric Surgery, Department of Surgery, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba and Children's Hospital Research Institute of Manitoba, AE402-820 Sherbrook Street, Winnipeg, MB, R3A 1S1, Canada.
Marietta JankDivision of Pediatric Surgery, Department of Surgery, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba and Children's Hospital Research Institute of Manitoba, AE402-820 Sherbrook Street, Winnipeg, MB, R3A 1S1, Canada.
Daywin PatelDivision of Pediatric Surgery, Department of Surgery, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba and Children's Hospital Research Institute of Manitoba, AE402-820 Sherbrook Street, Winnipeg, MB, R3A 1S1, Canada.
Arzu OzturkDivision of Pediatric Surgery, Department of Surgery, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba and Children's Hospital Research Institute of Manitoba, AE402-820 Sherbrook Street, Winnipeg, MB, R3A 1S1, Canada.
Ophelia AubertDivision of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Xingbin AiDivision of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Atsuyuki YamatakaDepartment of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, Tokyo, Japan.
Richard KeijzerDivision of Pediatric Surgery, Department of Surgery, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba and Children's Hospital Research Institute of Manitoba, AE402-820 Sherbrook Street, Winnipeg, MB, R3A 1S1, Canada. Richard.keijzer@umanitoba.ca.

Funding

Walter-Benjamin scholarship from the German Research Foundation (Deutsche Forschungsgemeinschaft e.V., DFG 519368454
6 · The paper itself

Abstract

backgroundYes-associated protein (YAP) is implicated in congenital diaphragmatic hernia (CDH). This study aims to investigate the abundance of YAP and its inactive form, phosphorylated YAP (p-YAP), in fetal human lung tissues from CDH cases compared to control cases at mid-gestation and end-gestation.

methodsImmunofluorescence was performed to assess the abundance of YAP and p-YAP in lung tissues from human CDH and control fetuses who died from causes other than CDH. Additionally, the impact on cellular differentiation was evaluated by assessing the expression of Homeodomain-only protein X (HOPX) and Surfactant protein C (SPC).

resultsImmunostaining revealed a higher abundance of YAP and p-YAP in both mid-gestation and end-gestation lung tissues. Notably, the abundance of p-YAP was increased in CDH tissues compared to controls, indicating higher levels of the inactive form of YAP in CDH. HOPX and SPC staining showed CDH tissues had a higher number of SPC-positive cells and fewer HOPX-positive cells at end-gestation.

conclusionsOur findings suggest that in CDH, YAP is predominantly present in its inactive form, p-YAP, potentially disrupting normal lung development and differentiation. This underscores the potential involvement of YAP dysregulation in the pathogenesis of CDH.

Indexed as

Hernias, Diaphragmatic, CongenitalTranscription FactorsYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingFemaleGestational AgeHumansLungPhosphoproteinsPregnancyAdaptor Proteins, Signal TransducingPhosphoproteinsTranscription FactorsYAP1 protein, humanYAP-Signaling ProteinsCongenital diaphragmatic herniaHippo signaling pathwayPulmonary hypoplasiaYes-associated protein

Identifiers

PMID39621187

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.