Evidence map›Paper›PMID 39621173›Full record

ReviewCancer metastasis reviews2024

Ribosomal rodeo: wrangling translational machinery in gynecologic tumors.

Kamil Filipek, Marianna Penzo

Abstract readReview
In one paragraph

Review in Cancer metastasis reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kamil FilipekDepartment of Medical and Surgical Sciences, and Center for Applied Biomedical Research, Alma Mater Studiorum University of Bologna, Bologna, Italy.ORCID 0000-0002-3139-5901
Marianna PenzoDepartment of Medical and Surgical Sciences, and Center for Applied Biomedical Research, Alma Mater Studiorum University of Bologna, Bologna, Italy. marianna.penzo@unibo.it.ORCID 0000-0002-1738-9767

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gynecologic cancers are a significant cause of morbidity and mortality among women worldwide. Despite advancements in diagnosis and treatment, the molecular mechanisms underlying the development and progression of these cancers remain poorly understood. Recent studies have implicated translational machinery (ribosomal proteins (RPs) and translation factors (TFs)) as potential drivers of oncogenic processes in various cancer types, including gynecologic cancers. RPs are essential components of the ribosome, which is responsible for protein synthesis. In this review paper, we aim to explore the role of translational machinery in gynecologic cancers. Specifically, we will investigate the potential mechanisms by which these components contribute to the oncogenic processes in these cancers and evaluate the feasibility of targeting RPs as a potential therapeutic strategy. By doing so, we hope to provide a broader view of the molecular pathogenesis of gynecologic cancers and highlight their potential as novel therapeutic targets for the management of these challenging diseases.

Indexed as

Genital Neoplasms, FemaleProtein BiosynthesisRibosomal ProteinsAnimalsFemaleHumansRibosomesRibosomal ProteinsCervical cancerEndometrial cancerOvarian cancerRibosomeRPLRPS

Identifiers

PMID39621173
PMCPMC11611960

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.