Evidence map›Paper›PMID 39621097›Full record

SynthesisClinical research in cardiology : official journal of the German Cardiac Society2025

Long-term outcomes with medical therapy, transcatheter repair, or surgery for isolated tricuspid regurgitation: a systematic review and network meta-analysis.

Tetsuya Saito, Toshiki Kuno, Tadao Aikawa, Hiroki A Ueyama, Polydoros N Kampaktsis, Dhaval Kolte, Naoki Misumida, Hisato Takagi, Yousif Ahmad, Tsuyoshi Kaneko and 2 more

Abstract readSystematic ReviewNetwork Meta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Clinical research in cardiology : official journal of the German Cardiac Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tetsuya SaitoDepartment of Cardiology, Edogawa Hospital, Tokyo, Japan.
Toshiki Kuno *Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 800, Boston, MA, 02114, USA. kuno-toshiki@hotmail.co.jp.ORCID http://orcid.org/0000-0002-2487-8366
Tadao AikawaDepartment of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Hiroki A UeyamaDivision of Cardiology, Emory University School of Medicine, Atlanta, GA, USA.
Polydoros N KampaktsisStructural and Congenital Center, Hackensack Medical Center, Hackensack, NJ, USA.
Dhaval KolteCardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Naoki MisumidaDivision of Cardiovascular Medicine, Gill Heart and Vascular Institute, University of Kentucky, Lexington, KY, USA.
Hisato TakagiDepartment of Cardiovascular Surgery, Shizuoka Medical Center, Shizuoka, Japan.
Yousif AhmadDivision of Cardiology, Department of Cardiology, University of California San Francisco, San Francisco, CA, USA.
Tsuyoshi KanekoCardiothoracic Surgery Division, Department of Surgery, Washington University in St Louis School of Medicine, St Louis, MO, USA.
Alan ZajariasCardiovascular Division, Department of Medicine, Washington University in St Louis School of Medicine, St Louis, MO, USA.
Azeem Latib *Division of Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral transcatheter tricuspid valve (TV) repair devices for tricuspid regurgitation (TR) have emerged. However, few studies have compared transcatheter TV repair with medical therapy (MT) alone or isolated TV surgery.

methodsPubMed and EMBASE were searched in February 2024. Studies comparing at least any of the following 2 were included: MT, surgical TV repair, surgical TV replacement, or transcatheter TV repair. The primary outcome was long-term mortality (≧ 1 year). The secondary outcomes were short-term mortality (30-day or in-hospital mortality) and periprocedural complications. We performed a network meta-analysis using a random effects model.

resultsA total of 25,831 patients from 22 studies (one randomized trial and 21 observational studies) were included. MT alone was associated with higher long-term mortality compared to surgical TV repair (HR [95% CI] 1.72 [1.34-2.23]), surgical TV replacement (HR [95% CI] 1.49 [1.14-1.96]), and transcatheter TV repair (HR [95% CI] 1.52 [1.30-1.78]). Long-term mortality was comparable between transcatheter and surgical interventions. Transcatheter TV repair had a lower risk of short-term mortality (versus surgical TV repair; RR [95% CI] 0.40 [0.22-0.72], versus surgical TV replacement; RR [95% CI] 0.35 [0.19-0.66]) and lower rates of periprocedural complications, including new pacemaker implantation, renal complications, cardiogenic shock than surgical interventions.

conclusionsMT alone for TR was associated with higher long-term mortality compared to surgical or transcatheter TV interventions. Transcatheter TV repair had better periprocedural outcomes compared to surgical interventions with similar long-term mortality. Despite the possibility of selection bias, transcatheter TV repair appears to be an attractive option for TR treatment.

Indexed as

Cardiac CatheterizationHeart Valve Prosthesis ImplantationTricuspid ValveTricuspid Valve InsufficiencyGlobal HealthHumansTime FactorsTreatment OutcomeSurgical tricuspid valve repairSurgical tricuspid valve replacementTranscatheter tricuspid valve repairTricuspid regurgitation

Identifiers

PMID39621097

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.