Evidence map›Paper›PMID 39621090›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Rosiridin prevents cisplatin-induced renal toxicity by inhibiting caspase-3/NF-κB/ Bcl-2 signaling pathways in rats and in silico study.

Imran Kazmi, Hisham N Altayb, Fahad A Al-Abbasi, Khalid Saad Alharbi, Naif A R Almalki, Ehssan Moglad, Salwa D Al-Qahtani, Azizah Salim Bawadood, Nadeem Sayyed

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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Imran KazmiDepartment of Biochemistry, Faculty of Sciences, King Abdulaziz University, 21589, Jeddah, Saudi Arabia. ikazmi@kau.edu.sa.
Hisham N AltaybDepartment of Biochemistry, Faculty of Sciences, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Fahad A Al-AbbasiDepartment of Biochemistry, Faculty of Sciences, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Khalid Saad AlharbiDepartment of Pharmacology and Toxicology, College of Pharmacy, Qassim University, 51452, Buraydah, Al Qassim, Saudi Arabia.
Naif A R AlmalkiDepartment of Biochemistry, Faculty of Sciences, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Ehssan MogladDepartment of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia.
Salwa D Al-QahtaniDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, 11952, Al Majmaah, Saudi Arabia.
Azizah Salim BawadoodBasic Medical Sciences Department, College of Medicine, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia.
Nadeem SayyedSchool of Pharmacy, Glocal University, Saharanpur, 247121, India. snadeem.pharma@gmail.com.

Funding

Deanship of Research (DSR), King Abdulaziz University, Jeddah G: 580-130-1446
6 · The paper itself

Abstract

The present investigation determines the effects of rosiridin in cisplatin (CP)-induced renal toxicity in rats. The experimental animals were used and divided into four groups. Experimental rats were randomly divided into group-I normal control, group-II CP group (8 mg/kg i.p.), group-III CP + rosiridin (10 mg/kg, p.o.) and group-IV rosiridin (10 mg/kg p.o.). Various biochemical parameters, i.e., creatinine, urea, uric acid, cholesterol, blood urea nitrogen, antioxidant levels, inflammatory markers such as interleukins-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α), nuclear factor kappa B (NF-κB), apoptosis markers including B cell lymphoma-2 (Bcl-2), caspase-3 and histopathological investigations were evaluated. Additionally, molecular docking and dynamics were performed to assess the interaction of rosiridin with target proteins. Rosiridin significantly minimized alteration in creatinine, urea, uric acid, cholesterol, blood urea nitrogen, antioxidant levels, and inflammatory, i.e., IL-1β, IL-6, TNF-α, NF-κB, Bcl-2, and caspase-3 which CP induced in rats. The interaction of rosiridin showed a favorable docking energy. The MD simulation results showed the higher stability of the complex generated from rosiridin. The current study exhibited rosiridin having a protective effect on CP-induced renal toxicity.

Indexed as

CisplatinKidneyNF-kappa BProto-Oncogene Proteins c-bcl-2AnimalsAntineoplastic AgentsApoptosisCaspase 3MaleMolecular Docking SimulationRatsRats, WistarSignal TransductionAntineoplastic AgentsBcl2 protein, ratCasp3 protein, ratCaspase 3CisplatinNF-kappa BProto-Oncogene Proteins c-bcl-2Antiapoptic effectAnti-inflammatory effectsCisplatinRenal toxicityRosiridin

Identifiers

PMID39621090

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.