ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2024
Exercising and immuno-oncology treatment (ExIO): a prospective pilot study for patients with solid tumors.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Functional exercise, fear of recurrence, and sleep quality: a longitudinal path analysis of quality of life in postoperative breast cancer patients.Frontiers in oncology · 2026Article
- International perspectives on exercise oncology: current state, challenges, and opportunities for future development.Journal of the National Cancer Institute. Monographs · 2025Article
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Authors and funding
17 authors.
Funding
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Abstract
purposeDespite exercise's known benefits for cancer patients, little is understood about combining it with immune checkpoint inhibitors (ICI). This study aims to assess the feasibility and acceptability of a personalized physical activity program for cancer patients on ICI treatment and to investigate its effects on quality of life, ICI-related side effects, fatigue, and emotional symptoms.
methodsThis prospective study was conducted across eight cancer practices in a joint network in Brazil. Eligible cancer patients undergoing ICIs were recruited from June 2022 to January 2023. Participants completed a 12-week physical activity program with remote supervision. Baseline and 12-week assessments utilized the FACT-ICM, BFI, ESAS, PROMIS-Anxiety, and FCR-7 scales. Feasibility and acceptability were evaluated based on enrollment, retention, and adherence rates, with patient feedback collected at week 12. Linear mixed models were employed to assess outcomes.
resultsOut of 38 patients, 81% showed high adherence, 62% engaged in activities more than 4 days weekly, and 97% were satisfied with the program. The sample was mostly female (55%), median age of 60.5, primarily diagnosed with breast cancer (26%) and renal cell carcinoma (24%), with 60.5% having metastatic cancer. Sixty percent received ICI combined with chemotherapy. Significant improvements were observed over time in treatment-related side effects, emotional symptoms, and quality of life (p < 0.001).
conclusionThese findings endorse integrating an exercise program with remote supervision into the care of cancer patients undergoing ICI treatment. This intervention may positively impact symptom management and quality of life, offering a cost-effective approach in oncologic treatment and survivorship care globally.
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