Evidence map›Paper›PMID 39621042›Full record

ArticlePsychopharmacology2025

TSPO activation ameliorates maternal immune activation induced PV interneuron deficits via BDNF/TrkB signaling.

Ming-Jie Mao, Hui-Ling Yu, Qing-Zhen Liu, Ya-Zhou Wen, Ming Jiang, Hong-Mei Yuan, Hua-Bei Zeng, Li-Dong Zhang, Shan-Wu Feng

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Article in Psychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ming-Jie Mao *Department of Anesthesiology, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China.
Hui-Ling Yu *Department of Anesthesiology, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China.
Qing-Zhen Liu *Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
Ya-Zhou WenDepartment of Anesthesiology, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China.
Ming JiangDepartment of Anesthesiology, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China.
Hong-Mei YuanDepartment of Anesthesiology, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China.
Hua-Bei ZengDepartment of Anesthesiology, Suqian Maternity and Children's Hospital, Suqian, China. 734615504@qq.com.
Li-Dong ZhangDepartment of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China. ldzhang1968@163.com.
Shan-Wu FengDepartment of Anesthesiology, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China. shanwufeng@163.com.ORCID http://orcid.org/0000-0001-6328-9700

Funding

National Natural Science Foundation of China 81971045National Natural Science Foundation of China 82401410Science and Technology Development Fund of Nanjing Medical University NMUB20210124
6 · The paper itself

Abstract

rationalePrenatal maternal immune activation (MIA) is an etiological risk factor for schizophrenia in offspring. Recently, parvalbumin (PV) positive interneuron deficits has been considered a critical pathology of many psych-cognitive disorders. Nevertheless, whether and how prenatal MIA affected PV interneuron in offspring remains largely unknown.

objectivesHere, we aimed to assess the relationship between MIA with PV interneuron deficits in offspring, and explored the underling mechanisms. METHODS AND

resultsMouse model of MIA was induced using lipopolysaccharide (120 µg/kg) on gestational day 15-17. Open field, elevated plus maze, Y-Maze and novel object recognition tests were performed and local field potential was recorded on adult male offspring. PV interneuron, Translocator protein 18 kDa (TSPO), and BDNF/TrkB signaling were then evaluated. Using TPSO agonist and TrkB antagonist, the function of TSPO on PV interneuron deficits was elucidated. Our results showed that MIA induced cognitive symptoms in the adult male offspring, accompanied by down-regulated PV and TSPO expression as well as decreased theta oscillation. Notably, activating TSPO reversed MIA-induced PV interneuron defects and behavioral abnormalities. Furthermore, specific inhibition of BDNF/TrkB signaling intercepted the protective effect of TSPO activation on PV interneuron deficits.

conclusionsOur results highlight TSPO activation might prevented PV interneuron deficits and behavioral abnormalities after MIA via BDNF/TrkB signaling.

Indexed as

Brain-Derived Neurotrophic FactorInterneuronsPrenatal Exposure Delayed EffectsReceptors, GABAAnimalsBehavior, AnimalDisease Models, AnimalFemaleLipopolysaccharidesMaleMembrane GlycoproteinsMiceMice, Inbred C57BLParvalbuminsPregnancyReceptor, trkBBdnf protein, mouseBrain-Derived Neurotrophic FactorBzrp protein, mouseLipopolysaccharidesMembrane GlycoproteinsNtrk2 protein, mouseParvalbuminsReceptors, GABAReceptor, trkBBDNF/TrkB signalingCognitive impairmentMaternal immune activationParvalbumin interneuronSchizophreniaTranslocator protein (TSPO)

Identifiers

PMID39621042

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.