Evidence map›Paper›PMID 39621040›Full record

ArticleOncoimmunology2024

Blood immune profiling of Ethiopian patients with breast cancer highlights different forms of immune escape.

Meron Yohannes, Chiara Massa, Zelalem Desalegn, Kathrin Stückrath, Anja Mueller, Endale Anberber, Yonas Bekuretsion, Mathewos Assefa, Pablo Santos, Adamu Addissie and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncoimmunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Meron YohannesDepartment of Microbiology, Immunology & Parasitology, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia.
Chiara MassaInstitute of Translational Immunology, Brandenburg Medical School "Theodor Fontane", Brandenburg an der Havel, Germany.
Zelalem DesalegnDepartment of Microbiology, Immunology & Parasitology, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia.
Kathrin StückrathUniversity Clinic and Polyclinic for Gynecology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Anja MuellerInstitute of Medical Immunology, Medical Faculty, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Endale AnberberDepartment of Surgery, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia.
Yonas BekuretsionDepartment of Pathology, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia.
Mathewos AssefaDepartment of Oncology, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia.
Pablo SantosGlobal and Planetary Health Working Group, Institute of Medical Epidemiology, Biometrics and Informatics, Martin Luther University of Halle-Wittenberg, Halle (Saale), Germany.
Adamu AddissieGlobal and Planetary Health Working Group, Institute of Medical Epidemiology, Biometrics and Informatics, Martin Luther University of Halle-Wittenberg, Halle (Saale), Germany.
Marcus BauerGlobal and Planetary Health Working Group, Institute of Medical Epidemiology, Biometrics and Informatics, Martin Luther University of Halle-Wittenberg, Halle (Saale), Germany.
Claudia WickenhauserInstitute of Pathology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Lesley TaylorCity of Hope National Medical Center, Duarte, CA, USA.
Martina VetterGlobal and Planetary Health Working Group, Institute of Medical Epidemiology, Biometrics and Informatics, Martin Luther University of Halle-Wittenberg, Halle (Saale), Germany.
Eva Johanna KantelhardtGlobal and Planetary Health Working Group, Institute of Medical Epidemiology, Biometrics and Informatics, Martin Luther University of Halle-Wittenberg, Halle (Saale), Germany.
Tamrat AbebeDepartment of Microbiology, Immunology & Parasitology, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia.
Barbara SeligerInstitute of Translational Immunology, Brandenburg Medical School "Theodor Fontane", Brandenburg an der Havel, Germany.ORCID 0000-0002-5544-4958

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer (BC) is a leading cause of death worldwide, particularly also among African woman. In order to better stratify patients for the most effective (immuno-) therapy, an in depth characterization of the immune status of BC patients is required. In this study, a cohort of 65 Ethiopian patients with primary BC underwent immune profiling by multicolor flow cytometry on peripheral blood samples collected prior to surgery and to any other therapy. Comparison with peripheral blood samples from healthy donors highlighted a general activation of the immune system, accompanied by the presence of exhausted CD4

Indexed as

Breast NeoplasmsAdultAgedCD4-CD8 RatioCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesEthiopiaFemaleFlow CytometryHumansMiddle AgedTumor EscapeBiomarkerbloodbreast cancerimmune escape

Identifiers

PMID39621040
PMCPMC11622621

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.