ArticleBiomacromolecules2025
Quantification of Biomolecular Condensate Volume Reveals Network Swelling and Dissolution Regimes during Phase Transition.
Article in Biomacromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Biomolecular condensates in plant stress and development: recent advances and emerging concepts.Journal of experimental botany · 2026Review
- Distinguishing near- versus off-critical phase behaviors of intrinsically disordered proteins.Reports on progress in physics. Physical Society (Great Britain) · 2026Article
- Topography-driven movement of biomolecular condensates.PloS one · 2026Article
- Controlling interfacial protein adsorption, desorption and aggregation in biomolecular condensates.Nature communications · 2025Article
- Vortex-Generated Microdroplets Enable Simple, Rapid, and Low-Volume Measurement of Condensate Volume and Concentration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Differential stability and dynamics of DNA-based and RNA-based coacervates affect non-enzymatic RNA chemistry.Nature communications · 2025Article
- Selective Ion Binding and Uptake Shape the Microenvironment of Biomolecular Condensates.Journal of the American Chemical Society · 2025Article
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Authors and funding
2 authors.
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Abstract
Accurate determination of biomolecular condensate volume reveals that destabilization of condensates can lead to either swelling or shrinking of condensates, giving fundamental insights into the regulation of the volume of cellular condensates. Determination of the volume of biomolecular condensates and coacervate protocells is essential to investigate their precise composition and impact on (bio)chemical reactions that are localized inside the condensates. It is not a straightforward task, as condensates have tiny volumes, are highly viscous, and are prone to wetting. Here, we examine different strategies to determine condensate volume and introduce two new methods, with which condensate volumes of 1 μL or less (volume fraction 0.4%) can be determined with a standard deviation of 0.03 μL. Using these methods, we show that the swelling or shrinking of condensates depends on the degree of physical cross-linking. These observations are supported by Flory-Huggins theory and can have profound effects on condensates in cell biology.
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