Evidence map›Paper›PMID 39620339›Full record

ReviewCurrent diabetes reviews2026

Deciphering the Interlinked CXCR4-Mediated Feedback Loop Among Signaling Pathways in Diabetic Wound Healing.

Sandhanam Kuppusamy, Bedanta Bhattacharjee, Damanbhalang Rynjah, Pratap Kalita, Saikat Sen, Raja Chakraborty

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current diabetes reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sandhanam KuppusamyDepartment of Pharmacology, KMCH College of Pharmacy, Coimbatore, Tamil Nadu, 641048, India.ORCID 0009-0004-2457-4129
Bedanta BhattacharjeeSchool of Pharmaceutical Sciences, Girijananda Chowdhury University-Tezpur Campus, Assam, 784501, India.ORCID 0000-0002-8481-3214
Damanbhalang RynjahSchool of Pharmaceutical Sciences, Girijananda Chowdhury University-Tezpur Campus, Assam, 784501, India.ORCID 0000-0002-9880-7632
Pratap KalitaDepartment of Pharmaceutics, Pratiksha Institute of Pharmaceutical Sciences, Guwahati, Assam, 781026, India.ORCID 0000-0001-7174-7898
Saikat SenFaculty of Pharmaceutical Science, Assam Down Town University, Sankar Madhab Path, Gandhi Nagar, Panikhaiti, Guwahati, Assam, 781026, India.ORCID 0000-0002-5279-1532
Raja ChakrabortyInstitute of Pharmacy, Assam Don Bosco University, Sonapur, Assam, 782402, India.ORCID 0000-0002-2097-9178

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic chronic wounds and amputations are very serious complications of diabetes mellitus (DM) that result from an integration factor, including oxygen deprivation, elevated reactive oxygen species (ROS), reduced angiogenesis, and microbial invasion. These causative factors lead to tenacious wounds in an inflammatory state, which eventually results in tissue aging and necrosis. Wound healing in DM potentially targets C-X-C chemokine receptor type 4 (CXCR4) regulates several signalling pathways. The CXCR4 signalling pathway integrated with phospholipase C (PLC)/protein kinase-C (PKC) Ca

Indexed as

Diabetes MellitusReceptors, CXCR4Signal TransductionWound HealingAnimalsFeedback, PhysiologicalHumansCXCR4 protein, humanReceptors, CXCR4angiogenesisCXCR4diabetic woundMAPKsoxygen deprivation.SDF-1

Identifiers

PMID39620339

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.