Evidence map›Paper›PMID 39620155›Full record

ArticleCurrent transplantation reports2023

Exosomes as Modulators and Biomarkers of Transplant Immunity.

Liv Palma, Micaela Gentile, Nicholas Chun

Abstract read
In one paragraph

Article in Current transplantation reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Exosomes in ocular graft-versus-host disease: an overview.International journal of ophthalmology · 2026
    Review
  2. Exosome in HBV infection: current concepts and future perspectives.Frontiers in cellular and infection microbiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Liv PalmaTranslational Transplant Research Center and Barbara T. Murphy Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Micaela GentileUO Nefrologia, Dipartimento di Medicina e Chirurgia, Universita di Parma, Parma, Italy.
Nicholas ChunTranslational Transplant Research Center and Barbara T. Murphy Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Funding

Complement-Mediated Exosome Function in TransplantationR01AI172899 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Nicholas Chun · 2022 to 2026
$2.7M
NIAID NIH HHS R01 AI172899
6 · The paper itself

Abstract

Purpose of Review: Exosomes have garnered increasing interest due to their involvement in a wide array of biological processes, including immunity and regeneration. In this review, we outline our current understanding of the role of exosomes in modulating transplant immune responses and as biomarkers of allograft function or rejection. Recent Findings: The exosomal effect on post-transplant immunity is heterogeneous and context dependent. They are critical for priming anti-donor T cell immunity via semi-direct presentation but have also been shown to promote tolerance to graft-expressed non-inherited maternal antigens. Post-transplant, proteomic and gene expression profiling of exosomes collected from blood, urine, or bronchoalveolar lavage can discriminate between cellular and antibody-mediated rejection and as a potential early prognostication tool. Summary: Secreted by both the donor and recipient cells after solid organ transplantation, exosomes are mechanistic mediators of the allogeneic immunity and have shown promise as non-invasive biomarkers of graft function.

Indexed as

ExosomeExtracellular vesiclesRejectionToleranceTransplant biomarker

Identifiers

PMID39620155
PMCPMC11606580

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.