Evidence map›Paper›PMID 39620005›Full record

ArticleFood science & nutrition2024

Comparative effect of olive oil and flaxseed oil on drug induced hepatotoxicity in rats.

Waqas Ahmad Khan, Muhammad Inam-Ur-Raheem, Hina Rasheed, Muhammad Abdullah Butt, Farhan Saeed, Muhammad Afzaal, Faiyaz Ahmed, Noor Akram, Aasma Asghar, Gebremichael Gebremedhin Hailu

Abstract read
In one paragraph

Article in Food science & nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Waqas Ahmad KhanNational Institute of Food Science and Technology (NIFSAT), University of Agriculture Faisalabad Pakistan.
Muhammad Inam-Ur-RaheemNational Institute of Food Science and Technology (NIFSAT), University of Agriculture Faisalabad Pakistan.
Hina RasheedNational Institute of Food Science and Technology (NIFSAT), University of Agriculture Faisalabad Pakistan.
Muhammad Abdullah ButtDepartment of Food Science Government College University Faisalabad Faisalabad Pakistan.
Farhan SaeedDepartment of Food Science Government College University Faisalabad Faisalabad Pakistan.ORCID https://orcid.org/0000-0001-5340-4015
Muhammad AfzaalDepartment of Food Science Government College University Faisalabad Faisalabad Pakistan.ORCID https://orcid.org/0000-0001-9047-9075
Faiyaz AhmedDepartment of Basic Health Sciences, College of Applied Medical Sciences Qassim University Buraydah Saudi Arabia.
Noor AkramFood Safety & Biotechnology lab, Department of Food Science Government College University Faisalabad Faisalabad Pakistan.ORCID https://orcid.org/0000-0002-2100-6212
Aasma AsgharDepartment of Nutritional Sciences Government College University Faisalabad Faisalabad Pakistan.
Gebremichael Gebremedhin HailuFood Technology and Process Engineering Oda Bultum University Chiro Ethiopia.ORCID https://orcid.org/0000-0002-7376-0700

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigates the hepatoprotective effects of olive oil and flaxseed oil on chemically induced hepatotoxicity in rats by evaluating key biochemical parameters, including free fatty acids, iodine value, liver enzymes (ALP, ALT, AST), cholesterol, triglycerides, and HDL levels. The results demonstrated significant improvements in these markers with the administration of olive oil and flaxseed oil, either individually or in combination. The free fatty acid percentages and iodine values were consistent with the known nutritional properties of the oils. Notably, the combination of olive oil and flaxseed oil yielded the most substantial benefits, reducing ALP (115.53 ± 0.44 U/L), ALT (50.77 ± 1.46 U/L), and AST (52.12 ± 0.36 U/L) levels while improving lipid profiles by lowering cholesterol (135.4 ± 1.43 mg/dL) and triglyceride levels (57.14 ± 2.35 mg/dL) and increasing HDL levels (49.20 ± 0.45 mg/dL). These findings suggest that olive oil and flaxseed oil, due to their antioxidant and anti-inflammatory properties, can effectively mitigate liver damage and promote lipid metabolism. The study supports the potential therapeutic application of these oils in managing liver health and preventing hepatotoxicity.

Indexed as

anti‐inflammatoryantioxidantchemical toxicitydetoxifying chemicalsglucose metabolismhepatotoxicitylipid profilesliver diseases

Identifiers

PMID39620005
PMCPMC11606853

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.