ArticleFood science & nutrition2024
Kaempferol Reduces Cardiopulmonary Load and Muscular Damage in Repeated 400-m Sprints: A Double-Blind, Randomized, Placebo-Controlled Trial.
Article in Food science & nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Effects of kaempferol on weather-related pain: an open-label pilot study of subjective headache and other discomforts in pre-intervention and intervention periods in Japan.International journal of biometeorology · 2025Trial
- Acute kaempferol ingestion lowers oxygen uptake during submaximal exercise and improves high-intensity exercise capacity in well-trained male athletes.Physiological reports · 2025Trial
- Kaempferol: advances in biosynthesis, molecular mechanisms, and therapeutic applications.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Flavonoids as Nutraceuticals to Treat Inflammatory Diseases: Focusing on Quercetin, Kaempferol, Luteolin, Apigenin, Epicatechin and Their Effects on Hepatic, Nervous, and Pulmonary Systems.Foods (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants exposed to hypoxic conditions have been suggested to produce more biologically active phytochemicals than those exposed to normal oxygen levels. Previously, we investigated 314 highland crop species and showed that the flavonoid kaempferol extracted from a highland quinoa grain markedly increased mitochondrial metabolism and ATP production in a hypoxic environment in vitro. Thus, we hypothesized that kaempferol would be effective during exercise under harsh conditions, in which anaerobic metabolism occurs. This study adopted a double-blind, placebo-controlled, crossover design to investigate the effect of a single oral dose of kaempferol (10 mg) on the athletic performance-related indicators of 13 male university athletes (20.8 ± 0.7 years) who performed two consecutive 400-m runs with the shortest 90-min interval assuming qualifying and main races. Although no significant differences were observed in the 400-m race times between the placebo and kaempferol groups, kaempferol intake markedly reduced the respiratory and heart rates during the second run (
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