Evidence map›Paper›PMID 39619718›Full record

ArticleThe Saudi dental journal2024

The potential of exosomes from adipose-derived stromal-vascular fraction in Increasing Migration Activity of Human Dental Pulp Stromal Cells (in vitro

Sylva Dinie Alinda, Anggraini Margono, Indah Yulianto, Ike Dwi Maharti, Reizka Asadelia Rafmawan

Abstract read
In one paragraph

Article in The Saudi dental journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sylva Dinie AlindaConservative Dentistry Department, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
Anggraini MargonoConservative Dentistry Department, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
Indah YuliantoDermato Venereology Department, Faculty of Medicine, Universitas Sebelas Maret, Solo Surakarta, Indonesia.
Ike Dwi MahartiConservative Dentistry Department, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
Reizka Asadelia RafmawanBachelor Degree, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Migration of dental pulp stromal cells (DPSCs) significantly responds to wound healing after pulp injury. Deriving from low compliance characteristics, pulp tissue regeneration is challenging and depends on the microenvironmental signals. Exosomes can maintain and carry bioactive proteins that are crucial in cell communication. Adipose tissue-derived stromal vascular fraction (AD-SVF), a heterogeneous group of progenitor cells, is a promising source of exosomes. Objective: Discover the impact of exosomes derived from an adipose-derived stromal-vascular fraction (AD-SVF Exo) on human dental pulp stromal cells (hDPSCs) migration. Results: hDPSCs cultured expressed mesenchymal stem cell mesenchymal stem cell (MSC) markers and formed loose colonies with characteristic spindle-shaped morphology. AD-SVF Exo consisted of marker proteins CD9 and CD63, and NTA measurement demonstrated a diameter of 103 ± 24 nm in diameter with 1,6 x 10 Conclusion: According to the findings of this research, AD-SVF Exo successfully enhances the wound healing capabilities of hDPSCs by improved migration activity, with the highest result found in 0.1% AD-SVF Exo.

Indexed as

Adipose-derived Stromal-Vascular FractionCell migrationDental pulp stromal cellsExosomesRegenerative endodonticsWound healing

Identifiers

PMID39619718
PMCPMC11605707

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.