ArticleThe Saudi dental journal2024
Evaluating the effectiveness of various agents as interim preservative media for biopsy specimens: An experimental in vitro study.
Article in The Saudi dental journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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5 authors.
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Abstract
In the field of medicine, diagnosing diseases involves various steps, procedures, and protocols. Histopathological examination remains the gold standard for a definitive and accurate diagnosis. This process relies on an initial step of tissue fixation. Formaldehyde is a traditional fixative material and is typically used as 10% or 4% buffered solutions. However, significant health risks are associated with formaldehyde exposure. Our paper aimed to evaluate and compare variable media as a preservative agent. The study included eight groups as follows: (1) normal saline 0.9%; (2) local anesthesia with epinephrine (2% Lidocaine HCl/ 1:100,000 epi); (3) local anesthesia without epinephrine (3% Mepivacaine HCl/ plain); (4) distilled water; (5) Saliva collected from healthy male participants; (6) Milk (Almarai- full-fat fresh milk); (7) Propolis; and (8) l0% formalin. Three tissue samples from each group were fixed in 10% formalin for 24 h after being preserved for 6 h at ambient temperature in their respective media. All specimens were stained with Hematoxylin and Eosin. The following histological structures were assessed: (1) superficial 1/3 of the epithelium, (2) middle 1/3 of the epithelium, (3) lower 1/3 of the epithelium, (4) basement membrane/rete ridges, (5) fibrous connective tissue, (6) blood vessels/endothelial cells, (7) skeletal muscle, (8) adipose tissue, and (9) nerve bundles. A numerical rating system was employed to assess these components, with scores ranging from 1 to 4. Our findings suggest propolis has promising potential as a tissue fixative. This study highlighted the effectiveness of propolis as a preservative and fixative solution, which warrants further investigation.
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