Evidence map›Paper›PMID 39619660›Full record

ReviewFrontiers in cellular and infection microbiology2024

Periodontal bacteria influence systemic diseases through the gut microbiota.

Mengying Xi, Qijun Ruan, Sulan Zhong, Jiatong Li, Weijuan Qi, Congman Xie, Xiaoyan Wang, Nuerbiya Abuduxiku, Jia Ni

Abstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. [Aging-Associated Oral Microbiota Dysbiosis and Hypofunction: Their Role in Alzheimer's Disease Pathogenesis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. BeyondMedicina (Kaunas, Lithuania) · 2025
    Review
  12. Review
  13. Article
  14. Prevalence and Severity of Periodontitis in Patients with Ulcerative Colitis: A Case-Control Study.International journal of environmental research and public health · 2025
    Article
  15. The Oral Microbiome in Queensland Free-Ranging Koalas (Animals : an open access journal from MDPI · 2025
    Article
  16. Review
  17. Alzheimer's Disease andLife (Basel, Switzerland) · 2025
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mengying Xi *Department of Periodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
Qijun Ruan *Department of Periodontics, Shenzhen Longgang Otolaryngology hospital, Shenzhen, China.
Sulan ZhongDepartment of Periodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
Jiatong LiDepartment of Periodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
Weijuan QiDepartment of Periodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
Congman XieDepartment of Orthodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
Xiaoyan WangDepartment of Periodontics, Shenzhen Longgang Otolaryngology hospital, Shenzhen, China.
Nuerbiya AbuduxikuDepartment of Stomatology, The First People's Hospital of Kashi, Kashi, China.
Jia NiDepartment of Periodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many systemic diseases, including Alzheimer disease (AD), diabetes mellitus (DM) and cardiovascular disease, are associated with microbiota dysbiosis. The oral and intestinal microbiota are directly connected anatomically, and communicate with each other through the oral-gut microbiome axis to establish and maintain host microbial homeostasis. In addition to directly, periodontal bacteria may also be indirectly involved in the regulation of systemic health and disease through the disturbed gut. This paper provides evidence for the role of periodontal bacteria in systemic diseases via the oral-gut axis and the far-reaching implications of maintaining periodontal health in reducing the risk of many intestinal and parenteral diseases. This may provide insight into the underlying pathogenesis of many systemic diseases and the search for new preventive and therapeutic strategies.

Indexed as

DysbiosisGastrointestinal MicrobiomeAlzheimer DiseaseAnimalsBacteriaCardiovascular DiseasesDiabetes MellitusHumansMouthfecal microbiota transplantationgut dysbiosisoral dysbiosisoral-gut axisperiodontal bacteriasystemic diseases

Identifiers

PMID39619660
PMCPMC11604649

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.